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RAT Plekho1 (aa 1-408 )
Plekho1 Swiss-Prot #
Q5BJM5
Plekho1 Protein names
Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O

member 1)
Plekho1 Gene names
Plekho1
Organism
Rattus norvegicus (Rat)
Plekho1 Entry name
PKHO1_RAT

Plekho1 Codon-optimized cDNA Clone
Plekho1 CDNA Cat#
RPY0875
Tag
cDNA Plekho1 contains A 6x histidine tag
Condon optimized Plekho1 cDNA Formulation
Liquid
Condon optimized Plekho1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized Plekho1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Plekho1 Protein
Recombinant Plekho1 Protein Cat#
PY0875
Plekho1 Protein Source
Recombinant protein
Recombinant Plekho1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Plekho1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Plekho1 Protein Activity
N/A
Tag
Recombinant Plekho1 contains A 6x histidine tag
Recombinant Plekho1 protein Formulation
Liquid
Recombinant Plekho1 protein Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Plekho1 Protein or cDNA
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Plekho1 Protein family
Plekho1 Subcellular locations
Membrane. Nucleus. Cytoplasm.
Plekho1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its

interactions with actin capping protein (CP). May function to target CK2 to the

plasma membrane thereby serving as an adapter to facilitate the phosphorylation of

CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane.

Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1

activity (plasma membrane bound AP-1 regulator that translocates to the nucleus)

and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound

to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By

similarity).
Plekho1 Sequence databases
EMBL DDBJ GenBank
Plekho1 3D structure databases
ModBase
Plekho1 Protein-protein interaction databases
STRING
Plekho1 Proteomic databases
PRIDE
Plekho1 Genome annotation databases
Ensembl GeneID KEGG UCSC
Plekho1 Organism-specific databases
CTD MGI
Plekho1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
Plekho1 Gene expression databases
Bgee ArrayExpress Genevestigator
Plekho1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.