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HUMAN KISS1 (aa 19-138 )
KISS1 Swiss-Prot #
Q15726
KISS1 Protein names
Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54);

Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]
KISS1 Gene names
KISS1 PP5098
Organism
Homo sapiens (Human)
KISS1 Entry name
KISS1_HUMAN

KISS1 Codon-optimized cDNA Clone
KISS1 CDNA Cat#
RPY0093
Tag
cDNA KISS1 contains A 6x histidine tag
Condon optimized KISS1 cDNA Formulation
Liquid
Condon optimized KISS1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Condon optimized KISS1 cDNA Application (s)
Applications: 1. Codon-optimized cDNA sequence designed for

recombinant protein production in both E.coli and Mammalian cell. The

cDNA has been cloned into E.coli expression vector with 6x Histidine tag.

2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant KISS1 Protein
Recombinant KISS1 Protein Cat#
PY0093
KISS1 Protein Source
Recombinant protein
Recombinant KISS1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant KISS1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant KISS1 Protein Activity
N/A
Tag
Recombinant KISS1 contains A 6x histidine tag
Condon optimized KISS1 cDNA Formulation
Liquid
Condon optimized KISS1 cDNA Storage
−20℃ to −70℃. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant KISS1 Protein or cDNA
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KISS1 Protein family
KISS1 family
KISS1 Subcellular locations
Secreted.
KISS1 FUNCTION (According to UniProtKB/Swiss-Prot)
FUNCTION: Metastasis suppressor protein in malignant melanomas and in some

breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps

involving cytoskeletal reorganization. Generates a C-terminally amidated peptide,

metastin which functions as the endogenous ligand of the G-protein coupled

receptor GPR54. Activation of the receptor inhibits cell proliferation and cell

migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived

from the primary translation product, isolated in conditioned medium of first

trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular

Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a

paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the

trophoblast itself. The receptor is also essential for normal gonadotropin-released

hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a

pivotal factor in central regulation of the gonadotropic axis at puberty and in

adulthood.
KISS1 Sequence databases
EMBL DDBJ GenBank
KISS1 3D structure databases
ModBase
KISS1 Protein-protein interaction databases
STRING
KISS1 Proteomic databases
PRIDE
KISS1 Genome annotation databases
Ensembl GeneID KEGG UCSC
KISS1 Organism-specific databases
CTD MGI
KISS1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN InParanoid OrthoDB PhylomeDB OMA
KISS1 Gene expression databases
Bgee ArrayExpress Genevestigator
KISS1 Family and domain databases
InterPro PROSITE ProtoNet

FOR in vitro RESEARCH USE ONLY. NOT FOR USE IN HUMANS.