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Human PAFAH1B1 (aa 2- 410)
PAFAH1B1 Swiss Prot#
P43034
PAFAH1B1 Protein names
Platelet-activating factor acetylhydrolase IB subunit alpha (PAF

acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha)

(PAFAH alpha) (Lissencephaly-1 protein) (LIS-1)
PAFAH1B1 Gene names
PAFAH1B1 (LIS1) (MDCR) (MDS) (PAFAHA)
Organism
Human
PAFAH1B1 Entry name
LIS1_HUMAN
PAFAH1B1 Codon optimized cDNA Clone
PAFAH1B1 CDNA Cat#
RPI0040
cDNA Tag
cDNA PAFAH1B1 Contains A 6x histidine tag
Condon optimized PAFAH1B1 CDNA Formulation
Liquid
Condon optimized PAFAH1B1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PAFAH1B1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PAFAH1B1 Protein

Recombinant PAFAH1B1 Protein Cat#
PI0040
PAFAH1B1 Protein Source
Recombinant protein.
Recombinant PAFAH1B1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PAFAH1B1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PAFAH1B1 Protein Activity
N/A
Recombinant protein Tag
Recombinant PAFAH1B1 contains A 6x histidine tag
Recombinant PAFAH1B1 Protein Formulation
Liquid
Recombinant PAFAH1B1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PAFAH1B1 Protein family
WD repeat LIS1/nudF family
PAFAH1B1 Subcellular locations
Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome.

Cytoplasm > cytoskeleton > spindle. Nucleus membrane.
PAFAH1B1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Required for proper activation of Rho GTPases and actin

polymerization at the leading edge of locomoting cerebellar neurons and

postmigratory hippocampal neurons in response to calcium influx triggered

via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex

which inactivates platelet-activating factor (PAF) by removing the acetyl

group at the SN-2 position (By similarity). Positively regulates the activity of

the minus-end directed microtubule motor protein dynein. May enhance

dynein-mediated microtubule sliding by targeting dynein to the microtubule

plus end. Required for several dynein- and microtubule-dependent

processes such as the maintenance of Golgi integrity, the peripheral

transport of microtubule fragments and the coupling of the nucleus and

centrosome. Required during brain development for the proliferation of

neuronal precursors and the migration of newly formed neurons from the

ventricular/subventricular zone toward the cortical plate. Neuronal

migration involves a process called nucleokinesis, whereby migrating cells

extend an anterior process into which the nucleus subsequently

translocates. During nucleokinesis dynein at the nuclear surface may

translocate the nucleus towards the centrosome by exerting force on

centrosomal microtubules. May also play a role in other forms of cell

locomotion including the migration of fibroblasts during wound healing.
PAFAH1B1 Sequence databases
EMBL DDBJ GenBank
PAFAH1B1 3D structure databases
ModBase
PAFAH1B1 Protein-protein interaction databases
STRING
PAFAH1B1 Proteomic databases
PRIDE
PAFAH1B1 Genome annotation databases
Ensembl GeneID KEGG UCSC
PAFAH1B1 Organism specific databases
CTD MGI
PAFAH1B1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PAFAH1B1 Gene expression databases
Bgee ArrayExpress Genevestigator
PAFAH1B1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY