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Human DNA excision repair protein ERCC-8 (a.a.1-396)
ERCC8 Swiss Prot#
Q13216
ERCC8 Protein names
DNA excision repair protein ERCC-8 (Cockayne syndrome WD repeat

protein CSA)
ERCC8 Gene names
ERCC8 CKN1 CSA
Organism
Human
ERCC8 Entry name
ERCC8_HUMAN
ERCC8 Codon optimized cDNA Clone
ERCC8 CDNA Cat#
RPS0189
cDNA Tag
cDNA ERCC8 Contains A 6x histidine tag
Condon optimized ERCC8 CDNA Formulation
Liquid
Condon optimized ERCC8 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized ERCC8 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant ERCC8 Protein
Recombinant ERCC8 Protein Cat#
PS0189
ERCC8 Protein Source
Recombinant protein.
Recombinant ERCC8 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ERCC8 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ERCC8 Protein Activity
N/A
Recombinant protein Tag
Recombinant ERCC8 contains A 6x histidine tag
Recombinant ERCC8 Protein Formulation
Liquid
Recombinant ERCC8 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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ERCC8 Protein family
-
ERCC8 Subcellular locations
Nucleus.
ERCC8 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Substrate-recognition component of the CSA complex, a DCX

(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in

transcription-coupled nucleotide excision repair. The CSA complex

(DCX(ERCC8) complex) promotes the ubiquitination and subsequent

proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6

degradation is essential for the recovery of RNA synthesis after

transcription-coupled repair. It is required for the recruitement of XAB2,

HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which

removes RNA polymerase II-blocking lesions from the transcribed strand of

active genes.
ERCC8 Sequence databases
EMBL DDBJ GenBank
ERCC8 3D structure databases
ModBase
ERCC8 Protein-protein interaction databases
STRING
ERCC8 Proteomic databases
PRIDE
ERCC8 Genome annotation databases
Ensembl GeneID KEGG UCSC
ERCC8 Organism specific databases
CTD MGI
ERCC8 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
ERCC8 Gene expression databases
Bgee ArrayExpress Genevestigator
ERCC8 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY