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Magnetic Separator
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Human Interferon regulatory factor 3 (a.a.1-427)
IRF3 Swiss Prot#
Q14653
IRF3 Protein names
Interferon regulatory factor 3 (IRF-3)
IRF3 Gene names
IRF3
Organism
Human
IRF3 Entry name
IRF3_HUMAN
IRF3 Codon optimized cDNA Clone
IRF3 CDNA Cat#
RPS0383
cDNA Tag
cDNA IRF3 Contains A 6x histidine tag
Condon optimized IRF3 CDNA Formulation
Liquid
Condon optimized IRF3 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized IRF3 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant IRF3 Protein
Recombinant IRF3 Protein Cat#
PS0383
IRF3 Protein Source
Recombinant protein.
Recombinant IRF3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant IRF3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant IRF3 Protein Activity
N/A
Recombinant protein Tag
Recombinant IRF3 contains A 6x histidine tag
Recombinant IRF3 Protein Formulation
Liquid
Recombinant IRF3 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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IRF3 Protein family
IRF family
IRF3 Subcellular locations
Cytoplasm. Nucleus.
IRF3 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Mediates interferon-stimulated response element (ISRE)

promoter activation. Functions as a molecular switch for antiviral activity.

DsRNA generated during the course of an viral infection leads to IRF3

phosphorylation on the C-terminal serine/threonine cluster. This induces a

conformational change, leading to its dimerization, nuclear localization and

association with CREB binding protein (CREBBP) to form dsRNA

factor 1 (DRAF1), a complex which activates the transcription of genes

under the control of ISRE. The complex binds to the IE and PRDIII regions

on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have

any transcription activation domains.
IRF3 Sequence databases
EMBL DDBJ GenBank
IRF3 3D structure databases
ModBase
IRF3 Protein-protein interaction databases
STRING
IRF3 Proteomic databases
PRIDE
IRF3 Genome annotation databases
Ensembl GeneID KEGG UCSC
IRF3 Organism specific databases
CTD MGI
IRF3 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
IRF3 Gene expression databases
Bgee ArrayExpress Genevestigator
IRF3 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY