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Human Methyl-CpG-binding domain protein 2 (a.a.1-411)
MBD2 Swiss Prot#
Q9UBB5
MBD2 Protein names
Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)

(Demethylase) (DMTase)
MBD2 Gene names
MBD2
Organism
Human
MBD2 Entry name
MBD2_HUMAN
MBD2 Codon optimized cDNA Clone
MBD2 CDNA Cat#
RPS0476
cDNA Tag
cDNA MBD2 Contains A 6x histidine tag
Condon optimized MBD2 CDNA Formulation
Liquid
Condon optimized MBD2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized MBD2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant MBD2 Protein
Recombinant MBD2 Protein Cat#
PS0476
MBD2 Protein Source
Recombinant protein.
Recombinant MBD2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant MBD2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant MBD2 Protein Activity
N/A
Recombinant protein Tag
Recombinant MBD2 contains A 6x histidine tag
Recombinant MBD2 Protein Formulation
Liquid
Recombinant MBD2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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MBD2 Protein family
-
MBD2 Subcellular locations
Nucleus.
MBD2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Binds CpG islands in promoters where the DNA is methylated at

position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA

as well. Recruits histone deacetylases and DNA methyltransferases. Acts

as transcriptional repressor and plays a role in gene silencing. Isoform 1

may enhance the activation of some unmethylated cAMP-responsive

promoters. Reports about DNA demethylase activity of isoform 2 are

contradictory.
MBD2 Sequence databases
EMBL DDBJ GenBank
MBD2 3D structure databases
ModBase
MBD2 Protein-protein interaction databases
STRING
MBD2 Proteomic databases
PRIDE
MBD2 Genome annotation databases
Ensembl GeneID KEGG UCSC
MBD2 Organism specific databases
CTD MGI
MBD2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
MBD2 Gene expression databases
Bgee ArrayExpress Genevestigator
MBD2 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY