Need Protein or cDNA?
Hundreds of thousands of  Recombinant
Proteins and Codon-optimized cDNAs
Available
Bio-Magnetic Purification
A Powerful Tool
for Life Science Research
  • Genomic DNA, cDNA, PCR, Plasmid DNA,
    RNA, mRNA
  • Antibody, Peptidde,protein
  • His-,GST-tag fusion protein
  • Endotoxin  removal
  • Streptavidin, Monoavidin
  • Affinity Magnetic Beads -quick  
    conjugation of any molecules
  • Ion Exchange Beads-WAX, SAX, WCX,
    SCX
  • Reversed-Phase Beads: C4, C8, C18
  • >>> >>>>
Gene Synthesis
  • Price: Call for quotation
  • 100% Accuracy
  • Codon Optimization: Free
  • Cloning into Any Vector: Free
  • Turnaround Time: 15 Days
  • >>> >>>
Recombinant Protein
Production & Purification
  • Just send us your  DNA template
    or Expression-ready Clone, we will return
    your highly-purified protein with low cost
Conjugation to Magnetic Beads
  • Send us your samples, we will conjugate
    them to our magnetic beads with low cost.
  • >>> >>>
New Products >>More
How to Order

Email: info@bioclone.us ;  order@bioclone.us
Online: GO >>>
Credit Card Order




GO >>>
Magnetic Separator
Magnetic Beads and Applications
Affinity Magnetic Beads
  • Amine-d
  • Aldehyde
  • Carboxyl-d
  • CDI-activated
  • DVS
  • DADPA-d
  • Epoxy
  • Hydrazide-d
  • Hydroxyl-d
  • Iodoacetyl
  • NHS
  • Sulfhydryl-d
  • Tosyl
  • Thiol
  • Silica
  • IDA-modified
Reversed-Phase  Beads
  • C4
  • C8
  • C18
  • Cyanopropyl
  • Phenyl
  • diPhenyl
Ion Exchange Beads
  • DEAE (WAX)
  • PSA (WAX)
  • SAX
  • WCX
  • SCX
  • Hydroxyapatite
Antibody Purification & IP
  • Protein A
  • Protein G
  • Protein A/G
  • Protein L
  • Quick IgG Pure Beads
  • Antigen Peptide
  • Quick IgM Pure Beads
  • Anti-IgG Beads
  • Quick IgA Pure Bead
  • Thiophillic Beads
Antibody Immobilization
  • Protein A
  • Protein G
  • Protein A/G
  • Protein L
  • Epoxy
  • Aldehyde
  • Hydrazide-d
  • Carboxyl-d
  • Iodoacetyl
  • Thiol
Recombinant Protein
Purification
  • Ni+ Charged Beads
  • Co+ Charged Beads
  • Maltose
  • Calmodulin Beads
Peptide Immobilization
  • Epoxy
  • Aldehyde
  • Carboxyl-d
  • Amine-d
  • Iodoacetyl
  • Thiol
DNA/RNA Purification
  • Blood
  • Saliva
  • Stool
  • Food
  • Soil
  • PCR Products
  • mRNA
  • Heteroduplex DNA
    (Mutation Isolation)
DNA/RNA Immobilization
  • Genomic DNA/RNA
  • mRNA
Endotoxin Removal
Small Molecule
Immobilization
Carbohydrate
Immobilization
  • Epoxy
  • Aldehyde
  • Hydrazide-d
  • DVS
Abundant Protein Removal
  • HSA Removal
  • IgG Removal
  • HSA/IgG Removal
  • Abundant-10 Protein
  • Abundant-22 Protein
 
Cell Isolation
  • Virus
  • Bacteria
  • Cell
  • Parasites
EDTA-Magnetic BEads
Miscellaneous
  • NTP/Oligonucleotides
  • Enzyme
  • Antibody
  • Peptide
  • Boronic Acid
  • Disulfide Reductants
IDA-Magnetic Beads
Copyright  Bioclone Inc  All rights Reserved
DNA/RNA Purification
>>More
 Recombinant Protein
Purification >>More
 Antibody
Purification >>More
 Small Molecules
Immobilization >>More
 Peptide Immobilization
>>More
 Carbohydrates
Immobilization >>More
 Bacterial,viral,cell
Isolation >>More
  • For cDNA or Recombinant Protein Search ( Input Cat#,
    or Gene name, or Protein Name, or Accession Number
Tel: 1-858-909-0079
Fax: 1-858-909-0057
Email: info@bioclone.us ;  order@bioclone.us
Human E3 ubiquitin-protein ligase RNF8 (a.a.1-485)
RNF8 Swiss Prot#
O76064
RNF8 Protein names
E3 ubiquitin-protein ligase RNF8 (EC 6.3.2.-) (RING finger protein 8)
RNF8 Gene names
RNF8 KIAA0646
Organism
Human
RNF8 Entry name
RNF8_HUMAN
RNF8 Codon optimized cDNA Clone
RNF8 CDNA Cat#
RPS0730
cDNA Tag
cDNA RNF8 Contains A 6x histidine tag
Condon optimized RNF8 CDNA Formulation
Liquid
Condon optimized RNF8 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized RNF8 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RNF8 Protein
Recombinant RNF8 Protein Cat#
PS0730
RNF8 Protein Source
Recombinant protein.
Recombinant RNF8 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RNF8 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RNF8 Protein Activity
N/A
Recombinant protein Tag
Recombinant RNF8 contains A 6x histidine tag
Recombinant RNF8 Protein Formulation
Liquid
Recombinant RNF8 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Place Order for Recombinant RNF8 Protein or cDNA
For pricing and availability Click Here >>>
RNF8 Protein family
RNF8 family
RNF8 Subcellular locations
Nucleus. Midbody.
RNF8 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: E3 ubiquitin-protein ligase required for assembly of repair

proteins to sites of DNA damage. Catalyzes the 'Lys-63'-linked ubiquitination

of histone H2A and H2AX. Following DNA double-strand breaks (DSBs), it is

recruited to the sites of damage by ATM-phosphorylated MDC1, mediates the

ubiquitination of histones H2A and H2AX, thereby promoting the formation

of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Promotes the

formation of 'Lys-63'-linked polyubiquitin chains and functions with the

specific ubiquitin-conjugating UBE2N/UBC13. Substrates that are

polyubiquitinated at 'Lys-63' are usually not targeted for degradation.

Enforces the G2/M DNA damage checkpoint. Controls the recruitment of

UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites

following DNA double-strand breaks (DSBs). Ubiquitination of histone H2A

requires UBE2N but not MMS2 (UBE2V2). May also ubiquitinate histone H2B.

Catalyzes the 'Lys-63'-linked ubiquitination of PCNA. May be required for

proper exit from mitosis after spindle checkpoint activation and may

regulate cytokinesis. May play a role in the regulation of RXRA-mediated

transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.
RNF8 Sequence databases
EMBL DDBJ GenBank
RNF8 3D structure databases
ModBase
RNF8 Protein-protein interaction databases
STRING
RNF8 Proteomic databases
PRIDE
RNF8 Genome annotation databases
Ensembl GeneID KEGG UCSC
RNF8 Organism specific databases
CTD MGI
RNF8 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
RNF8 Gene expression databases
Bgee ArrayExpress Genevestigator
RNF8 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY