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Human E3 ubiquitin-protein ligase SIAH2 (a.a.1-324)
SIAH2 Swiss Prot#
O43255
SIAH2 Protein names
E3 ubiquitin-protein ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2)

(Siah-2) (hSiah2)
SIAH2 Gene names
SIAH2
Organism
Human
SIAH2 Entry name
SIAH2_HUMAN
SIAH2 Codon optimized cDNA Clone
SIAH2 CDNA Cat#
RPS0761
cDNA Tag
cDNA SIAH2 Contains A 6x histidine tag
Condon optimized SIAH2 CDNA Formulation
Liquid
Condon optimized SIAH2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized SIAH2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SIAH2 Protein
Recombinant SIAH2 Protein Cat#
PS0761
SIAH2 Protein Source
Recombinant protein.
Recombinant SIAH2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SIAH2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SIAH2 Protein Activity
N/A
Recombinant protein Tag
Recombinant SIAH2 contains A 6x histidine tag
Recombinant SIAH2 Protein Formulation
Liquid
Recombinant SIAH2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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SIAH2 Protein family
SINA (Seven in absentia) family
SIAH2 Subcellular locations
Cytoplasm. Nucleus.
SIAH2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and

subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases

accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a

thioester and then directly transfers the ubiquitin to targeted substrates.

Mediates E3 ubiquitin ligase activity either through direct binding to

substrates or by functioning as the essential RING domain subunit of larger

E3 complexes. Triggers the ubiquitin-mediated degradation of many

substrates, including proteins involved in transcription regulation

(POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic

protein (BAG1), and a protein involved in synaptic vesicle function in

neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell

cycle, transcription and signaling processes. Has some overlapping

function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2,

whereas SIAH1 can not. Promotes monoubiquitination of SNCA.
SIAH2 Sequence databases
EMBL DDBJ GenBank
SIAH2 3D structure databases
ModBase
SIAH2 Protein-protein interaction databases
STRING
SIAH2 Proteomic databases
PRIDE
SIAH2 Genome annotation databases
Ensembl GeneID KEGG UCSC
SIAH2 Organism specific databases
CTD MGI
SIAH2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
SIAH2 Gene expression databases
Bgee ArrayExpress Genevestigator
SIAH2 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY