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Human NAD-dependent deacetylase sirtuin-6 (a.a.1-355)

SIRT6 Swiss Prot#

Q8N6T7

SIRT6 Protein names

NAD-dependent deacetylase sirtuin-6 (EC 3.5.1.-) (SIR2-like protein 6)

SIRT6 Gene names

SIRT6 SIR2L6

Organism

Human

SIRT6 Entry name

SIRT6_HUMAN

SIRT6 Codon optimized cDNA Clone

SIRT6 CDNA Cat#

RPS0765

cDNA Tag

cDNA SIRT6 Contains A 6x histidine tag

Condon optimized SIRT6 CDNA Formulation

Liquid

Condon optimized SIRT6 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized SIRT6 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SIRT6 Protein

Recombinant SIRT6 Protein Cat#

PS0765

SIRT6 Protein Source

Recombinant protein.

Recombinant SIRT6 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant SIRT6 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant SIRT6 Protein Activity

N/A

Recombinant protein Tag

Recombinant SIRT6 contains A 6x histidine tag

Recombinant SIRT6 Protein Formulation

Liquid

Recombinant SIRT6 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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SIRT6 Protein family

Sirtuin family

SIRT6 Subcellular locations

Nucleus > nucleoplasm.

SIRT6 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: NAD-dependent protein deacetylase. Has deacetylase activity

towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone

H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates

'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate

the expression of a subset of NF-kappa-B target genes. Deacetylation of

nucleosomes interferes with RELA binding to target DNA. May be required

for the association of WRN with telomeres during S-phase and for normal

telomere maintenance. Required for genomic stability. Required for normal

IGF1 serum levels and normal glucose homeostasis. Modulates cellular

senescence and apoptosis. Regulates the production of TNF protein (By

similarity).

SIRT6 Sequence databases

EMBL

DDBJ

GenBank

SIRT6 3D structure databases

ModBase

SIRT6 Protein-protein interaction databases

STRING

SIRT6 Proteomic databases

PRIDE

SIRT6 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

SIRT6 Organism specific databases

CTD

MGI

SIRT6 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SIRT6 Gene expression databases

Bgee

ArrayExpress

Genevestigator

SIRT6 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY