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Human Breast cancer type 1 susceptibility protein (a.a.1641-1863)

BRCA1 Swiss Prot#

P38398

BRCA1 Protein names

Breast cancer type 1 susceptibility protein (EC 6.3.2.-) (RING finger protein

53)

BRCA1 Gene names

BRCA1 (RNF53)

Organism

Human

BRCA1 Entry name

BRCA1_HUMAN

BRCA1 Codon optimized cDNA Clone

BRCA1 CDNA Cat#

RPE0485

cDNA Tag

cDNA BRCA1 Contains A 6x histidine tag

Condon optimized BRCA1 CDNA Formulation

Liquid

Condon optimized BRCA1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized BRCA1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant BRCA1 Protein

Recombinant BRCA1 Protein Cat#

PE0485

BRCA1 Protein Source

Recombinant protein.

Recombinant BRCA1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant BRCA1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant BRCA1 Protein Activity

N/A

Recombinant protein Tag

Recombinant BRCA1 contains A 6x histidine tag

Recombinant BRCA1 Protein Formulation

Liquid

Recombinant BRCA1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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BRCA1 Protein family

BRCA1 Subcellular locations

Nucleus. Cytoplasm.

BRCA1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: E3 ubiquitin-protein ligase that specifically mediates the

formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in

DNA repair by facilitating cellular responses to DNA damage. It is unclear

whether it also mediates the formation of other types of polyubiquitin chains.

The E3 ubiquitin-protein ligase activity is required for its tumor suppressor

function. The BRCA1-BARD1 heterodimer coordinates a diverse range of

cellular pathways such as DNA damage repair, ubiquitination and

transcriptional regulation to maintain genomic stability. Regulates

centrosomal microtubule nucleation. Required for normal cell cycle

progression from G2 to mitosis. Required for appropriate cell cycle arrests

after ionizing irradiation in both the S-phase and the G2 phase of the cell

cycle. Involved in transcriptional regulation of P21 in response to DNA

damage. Required for FANCD2 targeting to sites of DNA damage. May

function as a transcriptional regulator. Inhibits lipid synthesis by binding to

inactive phosphorylated ACACA and preventing its dephosphorylation.

Contributes to homologous recombination repair (HRR) via its direct

interaction with PALB2, fine-tunes recombinational repair partly through its

modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair

machinery at DNA breaks.

BRCA1 Sequence databases

EMBL

DDBJ

GenBank

BRCA1 3D structure databases

ModBase

BRCA1 Protein-protein interaction databases

STRING

BRCA1 Proteomic databases

PRIDE

BRCA1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

BRCA1 Organism specific databases

CTD

MGI

BRCA1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BRCA1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

BRCA1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY