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Human G1/S-specific cyclin-D1 (a.a.1–295)

CCND1 Swiss Prot#

P24385

CCND1 Protein names

G1/S-specific cyclin-D1 (PRAD1 oncogene) (B-cell lymphoma 1 protein)

(BCL-1) (BCL-1 oncogene)

CCND1 Gene names

CCND1 (BCL1) (PRAD1)

Organism

Human

CCND1 Entry name

NPM_HUMAN

CCND1 Codon optimized cDNA Clone

CCND1 CDNA Cat#

RPE0570

cDNA Tag

cDNA CCND1 Contains A 6x histidine tag

Condon optimized CCND1 CDNA Formulation

Liquid

Condon optimized CCND1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized CCND1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant CCND1 Protein

Recombinant CCND1 Protein Cat#

PE0570

CCND1 Protein Source

Recombinant protein.

Recombinant CCND1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant CCND1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant CCND1 Protein Activity

N/A

Recombinant protein Tag

Recombinant CCND1 contains A 6x histidine tag

Recombinant CCND1 Protein Formulation

Liquid

Recombinant CCND1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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CCND1 Protein family

Cyclin family, Cyclin D subfamily

CCND1 Subcellular locations

Nucleus. Cytoplasm. Membrane.

CCND1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that

phosphorylates and inhibits members of the retinoblastoma (RB) protein

family including RB1 and regulates the cell-cycle during G(1)/S transition.

Phosphorylation of RB1 allows dissociation of the transcription factor E2F

from the RB/E2F complex and the subsequent transcription of E2F target

genes which are responsible for the progression through the G(1) phase.

Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are

major integrators of various mitogenenic and antimitogenic signals. Also

substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent

manner and repressing its transcriptional activity. Component of the ternary

complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and

activity of the cyclin D-CDK4 complex.

CCND1 Sequence databases

EMBL

DDBJ

GenBank

CCND1 3D structure databases

ModBase

CCND1 Protein-protein interaction databases

STRING

CCND1 Proteomic databases

PRIDE

CCND1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

CCND1 Organism specific databases

CTD

MGI

CCND1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CCND1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

CCND1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY