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Human Disintegrin and metalloproteinase domain-containing protein 17 (a.a.215–671)
ADAM17 Swiss Prot#
P78536
ADAM17 Protein names
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)

(EC 3.4.24.86) (TNF-alpha-converting enzyme) (TNF-alpha convertase)

(Snake venom-like protease) (CD antigen CD156b)
ADAM17 Gene names
ADAM17 (CSVP) (TACE)
Organism
Human
ADAM17 Entry name
BLNK_HUMAN
ADAM17 Codon optimized cDNA Clone
ADAM17 CDNA Cat#
RPE0736
cDNA Tag
cDNA ADAM17 Contains A 6x histidine tag
Condon optimized ADAM17 CDNA Formulation
Liquid
Condon optimized ADAM17 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized ADAM17 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant ADAM17 Protein
Recombinant ADAM17 Protein Cat#
PE0736
ADAM17 Protein Source
Recombinant protein.
Recombinant ADAM17 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ADAM17 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ADAM17 Protein Activity
N/A
Recombinant protein Tag
Recombinant ADAM17 contains A 6x histidine tag
Recombinant ADAM17 Protein Formulation
Liquid
Recombinant ADAM17 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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ADAM17 Protein family
-
ADAM17 Subcellular locations
Membrane; Single-pass type I membrane protein.
ADAM17 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its

mature soluble form. Responsible for the proteolytic release of several

other cell-surface proteins, including p75 TNF-receptor, interleukin 1

receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-

selectin, growth hormone receptor, MUC1 and the amyloid precursor

protein. Also involved in the activation of Notch pathway (By similarity).
ADAM17 Sequence databases
EMBL DDBJ GenBank
ADAM17 3D structure databases
ModBase
ADAM17 Protein-protein interaction databases
STRING
ADAM17 Proteomic databases
PRIDE
ADAM17 Genome annotation databases
Ensembl GeneID KEGG UCSC
ADAM17 Organism specific databases
CTD MGI
ADAM17 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
ADAM17 Gene expression databases
Bgee ArrayExpress Genevestigator
ADAM17 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY