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Human CHMP1A (CHMP1) (KIAA0047) (PCOLN3) (PRSM1) (a.a.1-196)

CHMP1A Swiss Prot#

Q9HD42

CHMP1A Protein names

Charged multivesicular body protein 1a (Chromatin-modifying protein 1a)

(CHMP1a) (Vacuolar protein-sorting-associated protein 46-1) (Vps46-1)

(hVps46-1)

CHMP1A Gene names

CHMP1A (CHMP1) (KIAA0047) (PCOLN3) (PRSM1)

Organism

Human

CHMP1A Entry name

CHM1A_HUMAN

CHMP1A Codon optimized cDNA Clone

CHMP1A CDNA Cat#

RPE0041

cDNA Tag

cDNA CHMP1A Contains A 6x histidine tag

Condon optimized CHMP1A CDNA Formulation

Liquid

Condon optimized CHMP1A CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized CHMP1A cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant CHMP1A Protein

Recombinant CHMP1A Protein Cat#

PE0041

CHMP1A Protein Source

Recombinant protein.

Recombinant CHMP1A Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant CHMP1A Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant CHMP1A Protein Activity

N/A

Recombinant protein Tag

Recombinant CHMP1A contains A 6x histidine tag

Recombinant CHMP1A Protein Formulation

Liquid

Recombinant CHMP1A Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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CHMP1A Protein family

SNF7 family

CHMP1A Subcellular locations

Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus

matrix.

CHMP1A FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Probable peripherally associated component of the endosomal

sorting required for transport complex III (ESCRT-III) which is involved in

multivesicular bodies (MVBs) formation and sorting of endosomal cargo

proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are

generated by invagination and scission from the limiting membrane of the

endosome and mostly are delivered to lysosomes enabling degradation of

membrane proteins, such as stimulated growth factor receptors, lysosomal

enzymes and lipids. The MVB pathway appears to require the sequential

function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly

dissociate from the invaginating membrane before the ILV is released. The

ESCRT machinery also functions in topologically equivalent membrane

fission events, such as the terminal stages of cytokinesis and the budding

of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are

believed to mediate the necessary vesicle extrusion and/or membrane

fission activities, possibly in conjunction with the AAA ATPase VPS4.

Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the

midbody of dividing cells. May also be involved in chromosome

condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to

regions of condensed chromatin. May play a role in stable cell cycle

progression and in PcG gene silencing.

CHMP1A Sequence databases

EMBL

DDBJ

GenBank

CHMP1A 3D structure databases

ModBase

CHMP1A Protein-protein interaction databases

STRING

CHMP1A Proteomic databases

PRIDE

CHMP1A Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

CHMP1A Organism specific databases

CTD

MGI

CHMP1A Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CHMP1A Gene expression databases

Bgee

ArrayExpress

Genevestigator

CHMP1A Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY