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Human Baculoviral IAP repeat-containing protein 5 (a.a.1–142)

BIRC5 Swiss Prot#

O15392

BIRC5 Protein names

Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin)

(Apoptosis inhibitor 4)

BIRC5 Gene names

BIRC5 (API4) (IAP4)

Organism

Human

BIRC5 Entry name

BIRC5_HUMAN

BIRC5 Codon optimized cDNA Clone

BIRC5 CDNA Cat#

RPE0419

cDNA Tag

cDNA BIRC5 Contains A 6x histidine tag

Condon optimized BIRC5 CDNA Formulation

Liquid

Condon optimized BIRC5 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized BIRC5 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant BIRC5 Protein

Recombinant BIRC5 Protein Cat#

PE0419

BIRC5 Protein Source

Recombinant protein.

Recombinant BIRC5 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant BIRC5 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant BIRC5 Protein Activity

N/A

Recombinant protein Tag

Recombinant BIRC5 contains A 6x histidine tag

Recombinant BIRC5 Protein Formulation

Liquid

Recombinant BIRC5 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Place Order for Recombinant BIRC5 Protein or cDNA

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BIRC5 Protein family

IAP family

BIRC5 Subcellular locations

Cytoplasm. Nucleus. Chromosome. Chromosome > centromere. Cytoplasm

> cytoskeleton > spindle.

BIRC5 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Component of the chromosomal passenger complex (CPC), a

complex that acts as a key regulator of mitosis. The CPC complex has

essential functions at the centromere in ensuring correct chromosome

alignment and segregation and is required for chromatin-induced

microtubule stabilization and spindle assembly. The complex with RAN plays

a role in mitotic spindle formation by serving as a physical scaffold to help

deliver the RAN effector molecule TPX2 to microtubules. May play a role in

neoplasia. May counteract a default induction of apoptosis in G2/M phase.

Inhibitor of caspase-3 and caspase-7. Isoform 2 and isoform 3 do not appear

to play vital roles in mitosis. Isoform 3 shows a marked reduction in its

anti-apoptotic effects when compared with the displayed wild-type isoform.

BIRC5 Sequence databases

EMBL

DDBJ

GenBank

BIRC5 3D structure databases

ModBase

BIRC5 Protein-protein interaction databases

STRING

BIRC5 Proteomic databases

PRIDE

BIRC5 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

BIRC5 Organism specific databases

CTD

MGI

BIRC5 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BIRC5 Gene expression databases

Bgee

ArrayExpress

Genevestigator

BIRC5 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY