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Human Serine/threonine-protein kinase Chk2 (a.a.220–486)
CHEK2 Swiss Prot#
O96017
CHEK2 Protein names
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1)
CHEK2 Gene names
CHEK2 (CHK2) (RAD53)
Organism
Human
CHEK2 Entry name
NMDZ1_HUMAN
CHEK2 Codon optimized cDNA Clone
CHEK2 CDNA Cat#
RPE0826
cDNA Tag
cDNA CHEK2 Contains A 6x histidine tag
Condon optimized CHEK2 CDNA Formulation
Liquid
Condon optimized CHEK2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized CHEK2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant CHEK2 Protein
Recombinant CHEK2 Protein Cat#
PE0826
CHEK2 Protein Source
Recombinant protein.
Recombinant CHEK2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant CHEK2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant CHEK2 Protein Activity
N/A
Recombinant protein Tag
Recombinant CHEK2 contains A 6x histidine tag
Recombinant CHEK2 Protein Formulation
Liquid
Recombinant CHEK2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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CHEK2 Protein family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CHK2

subfamily
CHEK2 Subcellular locations
Nucleus. Nucleus > PML body. Nucleus > nucleoplasm.
CHEK2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Regulates cell cycle checkpoints and apoptosis in response to

DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C

phosphatase by phosphorylation on 'Ser-216', preventing the entry into

mitosis. May also play a role in meiosis. Regulates the TP53 tumor

suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.
CHEK2 Sequence databases
EMBL DDBJ GenBank
CHEK2 3D structure databases
ModBase
CHEK2 Protein-protein interaction databases
STRING
CHEK2 Proteomic databases
PRIDE
CHEK2 Genome annotation databases
Ensembl GeneID KEGG UCSC
CHEK2 Organism specific databases
CTD MGI
CHEK2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CHEK2 Gene expression databases
Bgee ArrayExpress Genevestigator
CHEK2 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY