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Human DNA excision repair protein ERCC-6 (a.a.519–695)
ERCC6 Swiss Prot#
Q03468
ERCC6 Protein names
DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase

ERCC6) (Cockayne syndrome protein CSB)
ERCC6 Gene names
ERCC6 (CSB)
Organism
Human
ERCC6 Entry name
ERCC6_HUMAN
ERCC6 Codon optimized cDNA Clone
ERCC6 CDNA Cat#
RPE0437
cDNA Tag
cDNA ERCC6 Contains A 6x histidine tag
Condon optimized ERCC6 CDNA Formulation
Liquid
Condon optimized ERCC6 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized ERCC6 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant ERCC6 Protein
Recombinant ERCC6 Protein Cat#
PE0437
ERCC6 Protein Source
Recombinant protein.
Recombinant ERCC6 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ERCC6 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ERCC6 Protein Activity
N/A
Recombinant protein Tag
Recombinant ERCC6 contains A 6x histidine tag
Recombinant ERCC6 Protein Formulation
Liquid
Recombinant ERCC6 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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ERCC6 Protein family
SNF2/RAD54 helicase family
ERCC6 Subcellular locations
Nucleus.
ERCC6 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Essential factor involved in transcription-coupled nucleotide

excision repair which allows RNA polymerase II-blocking lesions to be

rapidly removed from the transcribed strand of active genes. Upon DNA-

binding, it locally modifies DNA conformation by wrapping the DNA around

itself, thereby modifying the interface between stalled RNA polymerase II and

DNA. It is required for transcription-coupled repair complex formation. It

recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision

repair proteins and EP300 to the at sites of RNA polymerase II-blocking

lesions.
ERCC6 Sequence databases
EMBL DDBJ GenBank
ERCC6 3D structure databases
ModBase
ERCC6 Protein-protein interaction databases
STRING
ERCC6 Proteomic databases
PRIDE
ERCC6 Genome annotation databases
Ensembl GeneID KEGG UCSC
ERCC6 Organism specific databases
CTD MGI
ERCC6 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
ERCC6 Gene expression databases
Bgee ArrayExpress Genevestigator
ERCC6 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY