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Human Mediator of RNA polymerase II transcription subunit 28 (a.a.1-178)

MED28 Swiss Prot#

Q9H204

MED28 Protein names

Mediator of RNA polymerase II transcription subunit 28 (Mediator complex

subunit 28) (Tumor angiogenesis marker EG-1) (Endothelial-derived protein

1) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin)

MED28 Gene names

MED28 (EG1) (FKSG20)

Organism

Human

MED28 Entry name

MED28_HUMAN

MED28 Codon optimized cDNA Clone

MED28 CDNA Cat#

RPE0439

cDNA Tag

cDNA MED28 Contains A 6x histidine tag

Condon optimized MED28 CDNA Formulation

Liquid

Condon optimized MED28 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized MED28 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant MED28 Protein

Recombinant MED28 Protein Cat#

PE0439

MED28 Protein Source

Recombinant protein.

Recombinant MED28 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant MED28 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant MED28 Protein Activity

N/A

Recombinant protein Tag

Recombinant MED28 contains A 6x histidine tag

Recombinant MED28 Protein Formulation

Liquid

Recombinant MED28 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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MED28 Protein family

Mediator complex subunit 28 family

MED28 Subcellular locations

Nucleus. Cytoplasm. Membrane; Peripheral membrane protein.

MED28 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Component of the Mediator complex, a coactivator involved in

the regulated transcription of nearly all RNA polymerase II-dependent genes.

Mediator functions as a bridge to convey information from gene-specific

regulatory proteins to the basal RNA polymerase II transcription machinery.

Mediator is recruited to promoters by direct interactions with regulatory

proteins and serves as a scaffold for the assembly of a functional

preinitiation complex with RNA polymerase II and the general transcription

factors. May be part of a complex containing NF2/merlin that participates in

cellular signaling to the actin cytoskeleton downstream of tyrosine kinase

signaling pathways.

MED28 Sequence databases

EMBL

DDBJ

GenBank

MED28 3D structure databases

ModBase

MED28 Protein-protein interaction databases

STRING

MED28 Proteomic databases

PRIDE

MED28 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

MED28 Organism specific databases

CTD

MGI

MED28 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

MED28 Gene expression databases

Bgee

ArrayExpress

Genevestigator

MED28 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY