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Human Insulin-like growth factor 1 receptor (a.a.741–935)

IGF1R Swiss Prot#

P08069

IGF1R Protein names

Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I

receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like

growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor

beta chain]

IGF1R Gene names

IGF1R

Organism

Human

IGF1R Entry name

IGF1R_HUMAN

IGF1R Codon optimized cDNA Clone

IGF1R CDNA Cat#

RPE0456

cDNA Tag

cDNA IGF1R Contains A 6x histidine tag

Condon optimized IGF1R CDNA Formulation

Liquid

Condon optimized IGF1R CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized IGF1R cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant IGF1R Protein

Recombinant IGF1R Protein Cat#

PE0456

IGF1R Protein Source

Recombinant protein.

Recombinant IGF1R Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant IGF1R Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant IGF1R Protein Activity

N/A

Recombinant protein Tag

Recombinant IGF1R contains A 6x histidine tag

Recombinant IGF1R Protein Formulation

Liquid

Recombinant IGF1R Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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IGF1R Protein family

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor

subfamily

IGF1R Subcellular locations

Membrane; Single-pass type I membrane protein.

IGF1R FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: This receptor binds insulin-like growth factor 1 (IGF1) with a high

affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase

activity, which is necessary for the activation of the IGF1-stimulated

downstream signaling cascade. When present in a hybrid receptor with

INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed

of IGF1R and INSR isoform Long are activated with a high affinity by IGF1,

with low affinity by IGF2 and not significantly activated by insulin, and that

hybrid receptors composed of IGF1R and INSR isoform Short are activated

by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid

receptors composed of IGF1R and INSR isoform Long and hybrid receptors

composed of IGF1R and INSR isoform Short have similar binding

characteristics, both bind IGF1 and have a low affinity for insulin.

IGF1R Sequence databases

EMBL

DDBJ

GenBank

IGF1R 3D structure databases

ModBase

IGF1R Protein-protein interaction databases

STRING

IGF1R Proteomic databases

PRIDE

IGF1R Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

IGF1R Organism specific databases

CTD

MGI

IGF1R Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IGF1R Gene expression databases

Bgee

ArrayExpress

Genevestigator

IGF1R Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY