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Human Nuclear factor NF-kappa-B p105 subunit (a.a.1–433)

NFKB1 Swiss Prot#

P19838

NFKB1 Protein names

Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1)

[Cleaved into: Nuclear factor NF-kappa-B p50 subunit]

NFKB1 Gene names

NFKB1

Organism

Human

NFKB1 Entry name

CBP_HUMAN

NFKB1 Codon optimized cDNA Clone

NFKB1 CDNA Cat#

RPE0714

cDNA Tag

cDNA NFKB1 Contains A 6x histidine tag

Condon optimized NFKB1 CDNA Formulation

Liquid

Condon optimized NFKB1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized NFKB1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant NFKB1 Protein

Recombinant NFKB1 Protein Cat#

PE0714

NFKB1 Protein Source

Recombinant protein.

Recombinant NFKB1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant NFKB1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant NFKB1 Protein Activity

N/A

Recombinant protein Tag

Recombinant NFKB1 contains A 6x histidine tag

Recombinant NFKB1 Protein Formulation

Liquid

Recombinant NFKB1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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NFKB1 Protein family

NFKB1 Subcellular locations

Nucleus. Cytoplasm.

NFKB1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: NF-kappa-B is a pleiotropic transcription factor which is present

in almost all cell types and is involved in many biological processed such

as inflammation, immunity, differentiation, cell growth, tumorigenesis and

apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the

Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105,

NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex

appears to be most abundant one. The dimers bind at kappa-B sites in the

DNA of their target genes and the individual dimers have distinct

preferences for different kappa-B sites that they can bind with

distinguishable affinity and specificity. Different dimer combinations act as

transcriptional activators or repressors, respectively. NF-kappa-B is

controlled by various mechanisms of post-translational modification and

subcellular compartmentalization as well as by interactions with other

cofactors or corepressors.

NFKB1 Sequence databases

EMBL

DDBJ

GenBank

NFKB1 3D structure databases

ModBase

NFKB1 Protein-protein interaction databases

STRING

NFKB1 Proteomic databases

PRIDE

NFKB1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

NFKB1 Organism specific databases

CTD

MGI

NFKB1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

NFKB1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

NFKB1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY