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Human Prolow-density lipoprotein receptor-related protein 1 (a.a.4441–4544)

LRP1 Swiss Prot#

Q07954

LRP1 Protein names

Prolow-density lipoprotein receptor-related protein 1 (LRP) (Alpha-2-

macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD

antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related

protein 1 85 kDa subunit (LRP-85); Low-densit

LRP1 Gene names

LRP1 (A2MR) (APR)

Organism

Human

LRP1 Entry name

LRP1_HUMAN

LRP1 Codon optimized cDNA Clone

LRP1 CDNA Cat#

RPE0407

cDNA Tag

cDNA LRP1 Contains A 6x histidine tag

Condon optimized LRP1 CDNA Formulation

Liquid

Condon optimized LRP1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized LRP1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant LRP1 Protein

Recombinant LRP1 Protein Cat#

PE0407

LRP1 Protein Source

Recombinant protein.

Recombinant LRP1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant LRP1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant LRP1 Protein Activity

N/A

Recombinant protein Tag

Recombinant LRP1 contains A 6x histidine tag

Recombinant LRP1 Protein Formulation

Liquid

Recombinant LRP1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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LRP1 Protein family

LDLR family

LRP1 Subcellular locations

Cell membrane; Single-pass type I membrane protein. Membrane > coated

pit. Cell membrane; Peripheral membrane protein; Extracellular side.

Membrane > coated pit. Cytoplasm. Nucleus.

LRP1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Endocytic receptor involved in endocytosis and in phagocytosis

of apoptotic cells. Required for early embryonic development. Involved in

cellular lipid homeostasis. Involved in the plasma clearance of chylomicron

remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the

local metabolism of complexes between plasminogen activators and their

endogenous inhibitors. May modulate cellular events, such as APP

metabolism, kinase-dependent intracellular signaling, neuronal calcium

signaling as well as neurotransmission.

LRP1 Sequence databases

EMBL

DDBJ

GenBank

LRP1 3D structure databases

ModBase

LRP1 Protein-protein interaction databases

STRING

LRP1 Proteomic databases

PRIDE

LRP1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

LRP1 Organism specific databases

CTD

MGI

LRP1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

LRP1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

LRP1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY