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Human Protein disulfide-isomerase (a.a.18–508)
P4HB Swiss Prot#
P07237
P4HB Protein names
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Prolyl 4-hydroxylase subunit

beta) (Cellular thyroid hormone-binding protein) (p55)
P4HB Gene names
P4HB (ERBA2L) (PDI) (PDIA1) (PO4DB)
Organism
Human
P4HB Entry name
CP17A_HUMAN
P4HB Codon optimized cDNA Clone
P4HB CDNA Cat#
RPE0795
cDNA Tag
cDNA P4HB Contains A 6x histidine tag
Condon optimized P4HB CDNA Formulation
Liquid
Condon optimized P4HB CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized P4HB cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant P4HB Protein

Recombinant P4HB Protein Cat#
PE0795
P4HB Protein Source
Recombinant protein.
Recombinant P4HB Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant P4HB Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant P4HB Protein Activity
N/A
Recombinant protein Tag
Recombinant P4HB contains A 6x histidine tag
Recombinant P4HB Protein Formulation
Liquid
Recombinant P4HB Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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P4HB Protein family
Protein disulfide isomerase family
P4HB Subcellular locations
Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral

membrane protein.
P4HB FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: This multifunctional protein catalyzes the formation, breakage

and rearrangement of disulfide bonds. At the cell surface, seems to act as a

reductase that cleaves disulfide bonds of proteins attached to the cell. May

therefore cause structural modifications of exofacial proteins. Inside the

cell, seems to form/rearrange disulfide bonds of nascent proteins. At high

concentrations, functions as a chaperone that inhibits aggregation of

misfolded proteins. At low concentrations, facilitates aggregation (anti-

chaperone activity). May be involved with other chaperones in the structural

modification of the TG precursor in hormone biogenesis. Also acts a

structural subunit of various enzymes such as prolyl 4-hydroxylase and

microsomal triacylglycerol transfer protein MTTP.
P4HB Sequence databases
EMBL DDBJ GenBank
P4HB 3D structure databases
ModBase
P4HB Protein-protein interaction databases
STRING
P4HB Proteomic databases
PRIDE
P4HB Genome annotation databases
Ensembl GeneID KEGG UCSC
P4HB Organism specific databases
CTD MGI
P4HB Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
P4HB Gene expression databases
Bgee ArrayExpress Genevestigator
P4HB Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY