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Human Platelet endothelial cell adhesion molecule (a.a.28–601)
PECAM1 Swiss Prot#
P16284
PECAM1 Protein names
Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA')

(CD antigen CD31)
PECAM1 Gene names
PECAM1
Organism
Human
PECAM1 Entry name
CHLE_HUMAN
PECAM1 Codon optimized cDNA Clone
PECAM1 CDNA Cat#
RPE0850
cDNA Tag
cDNA PECAM1 Contains A 6x histidine tag
Condon optimized PECAM1 CDNA Formulation
Liquid
Condon optimized PECAM1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PECAM1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PECAM1 Protein
Recombinant PECAM1 Protein Cat#
PE0850
PECAM1 Protein Source
Recombinant protein.
Recombinant PECAM1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PECAM1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PECAM1 Protein Activity
N/A
Recombinant protein Tag
Recombinant PECAM1 contains A 6x histidine tag
Recombinant PECAM1 Protein Formulation
Liquid
Recombinant PECAM1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PECAM1 Protein family
-
PECAM1 Subcellular locations
Membrane; Single-pass type I membrane protein. Cell junction. Cell

junction.
PECAM1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Induces susceptibility to atherosclerosis (By similarity). Cell

adhesion molecule which is required for leukocyte transendothelial

migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical

role in TEM and is required for efficient trafficking of PECAM1 to and from

the lateral border recycling compartment (LBRC) and is also essential for

the LBRC membrane to be targeted around migrating leukocytes. Prevents

phagocyte ingestion of closely apposed viable cells by transmitting

'detachment' signals, and changes function on apoptosis, promoting

tethering of dying cells to phagocytes (the encounter of a viable cell with a

phagocyte via the homophilic interaction of PECAM1 on both cell surfaces

leads to the viable cell's active repulsion from the phagocyte. During

apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that

the apoptotic cell does not actively reject the phagocyte anymore. The lack

of this repulsion signal together with the interaction of the eat-me signals

and their respective receptors causes the attachment of the apoptotic cell

to the phagocyte, thus triggering the process of engulfment). Isoform Delta15

is unable to protect against apoptosis. Modulates BDKRB2 activation.

Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation

in human umbilical cord vein cells (HUVEC).
PECAM1 Sequence databases
EMBL DDBJ GenBank
PECAM1 3D structure databases
ModBase
PECAM1 Protein-protein interaction databases
STRING
PECAM1 Proteomic databases
PRIDE
PECAM1 Genome annotation databases
Ensembl GeneID KEGG UCSC
PECAM1 Organism specific databases
CTD MGI
PECAM1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PECAM1 Gene expression databases
Bgee ArrayExpress Genevestigator
PECAM1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY