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Human Prostaglandin-H2 D-isomerase (a.a.23–190)

PTGDS Swiss Prot#

P41222

PTGDS Protein names

Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Lipocalin-type prostaglandin-D

synthase) (Glutathione-independent PGD synthetase) (Prostaglandin-D2

synthase) (PGD2 synthase) (PGDS2) (PGDS) (Beta-trace protein) (Cerebrin-

28)

PTGDS Gene names

PTGDS (PDS)

Organism

Human

PTGDS Entry name

PTGDS_HUMAN

PTGDS Codon optimized cDNA Clone

PTGDS CDNA Cat#

RPE0449

cDNA Tag

cDNA PTGDS Contains A 6x histidine tag

Condon optimized PTGDS CDNA Formulation

Liquid

Condon optimized PTGDS CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized PTGDS cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PTGDS Protein

Recombinant PTGDS Protein Cat#

PE0449

PTGDS Protein Source

Recombinant protein.

Recombinant PTGDS Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant PTGDS Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant PTGDS Protein Activity

N/A

Recombinant protein Tag

Recombinant PTGDS contains A 6x histidine tag

Recombinant PTGDS Protein Formulation

Liquid

Recombinant PTGDS Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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PTGDS Protein family

Calycin superfamily, Lipocalin family

PTGDS Subcellular locations

Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus.

Cytoplasm > perinuclear region. Secreted.

PTGDS FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin

involved in smooth muscle contraction/relaxation and a potent inhibitor of

platelet aggregation. Involved in a variety of CNS functions, such as

sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-

apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic

molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid

hormone, and may act as a scavenger for harmful hydrophopic molecules

and as a secretory retinoid and thyroid hormone transporter. Possibly

involved in development and maintenance of the blood-brain, blood-retina,

blood-aqueous humor and blood-testis barrier. It is likely to play important

roles in both maturation and maintenance of the central nervous system and

male reproductive system.

PTGDS Sequence databases

EMBL

DDBJ

GenBank

PTGDS 3D structure databases

ModBase

PTGDS Protein-protein interaction databases

STRING

PTGDS Proteomic databases

PRIDE

PTGDS Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

PTGDS Organism specific databases

CTD

MGI

PTGDS Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PTGDS Gene expression databases

Bgee

ArrayExpress

Genevestigator

PTGDS Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY