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Human Cell division protein kinase 4 (a.a.6–295)

CDK4 Swiss Prot#

P11802

CDK4 Protein names

Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4)

(PSK-J3)

CDK4 Gene names

CDK4

Organism

Human

CDK4 Entry name

CASP7_HUMAN

CDK4 Codon optimized cDNA Clone

CDK4 CDNA Cat#

RPE0577

cDNA Tag

cDNA CDK4 Contains A 6x histidine tag

Condon optimized CDK4 CDNA Formulation

Liquid

Condon optimized CDK4 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized CDK4 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant CDK4 Protein

Recombinant CDK4 Protein Cat#

PE0577

CDK4 Protein Source

Recombinant protein.

Recombinant CDK4 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant CDK4 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant CDK4 Protein Activity

N/A

Recombinant protein Tag

Recombinant CDK4 contains A 6x histidine tag

Recombinant CDK4 Protein Formulation

Liquid

Recombinant CDK4 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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CDK4 Protein family

Protein kinase superfamily, CMGC Ser/Thr protein kinase family,

CDC2/CDKX subfamily

CDK4 Subcellular locations

Cytoplasm. Nucleus. Membrane.

CDK4 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that

phosphorylate and inhibit members of the retinoblastoma (RB) protein family

including RB1 and regulate the cell-cycle during G(1)/S transition.

Phosphorylation of RB1 allows dissociation of the transcription factor E2F

from the RB/E2F complexes and the subsequent transcription of E2F target

genes which are responsible for the progression through the G(1) phase.

Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are

major integrators of various mitogenenic and antimitogenic signals. Also

phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its

transcriptional activity. Component of the ternary complex, cyclin

D/CDK4/CDKN1B, required for nuclear translocation and activity of the

cyclin D-CDK4 complex.

CDK4 Sequence databases

EMBL

DDBJ

GenBank

CDK4 3D structure databases

ModBase

CDK4 Protein-protein interaction databases

STRING

CDK4 Proteomic databases

PRIDE

CDK4 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

CDK4 Organism specific databases

CTD

MGI

CDK4 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CDK4 Gene expression databases

Bgee

ArrayExpress

Genevestigator

CDK4 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY