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Human Pro-neuregulin-1, membrane-bound isoform (a.a.20–242)
NRG1 Swiss Prot#
Q02297
NRG1 Protein names
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into:

Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer

cell differentiation factor p45) (Acetylcholine receptor-inducing activity)

(ARIA) (Sensory and motor neuron-deri
NRG1 Gene names
NRG1 (GGF) (HGL) (HRGA) (NDF) (SMDF)
Organism
Human
NRG1 Entry name
NRG1_HUMAN
NRG1 Codon optimized cDNA Clone
NRG1 CDNA Cat#
RPE0483
cDNA Tag
cDNA NRG1 Contains A 6x histidine tag
Condon optimized NRG1 CDNA Formulation
Liquid
Condon optimized NRG1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized NRG1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant NRG1 Protein
Recombinant NRG1 Protein Cat#
PE0483
NRG1 Protein Source
Recombinant protein.
Recombinant NRG1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant NRG1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant NRG1 Protein Activity
N/A
Recombinant protein Tag
Recombinant NRG1 contains A 6x histidine tag
Recombinant NRG1 Protein Formulation
Liquid
Recombinant NRG1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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NRG1 Protein family
Neuregulin family
NRG1 Subcellular locations
Cell membrane; Single-pass type I membrane protein. Secreted. Nucleus.

Membrane; Single-pass type I membrane protein.
NRG1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors.

Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-

stimulated tyrosine phosphorylation and activation of the ERBB receptors.

The multiple isoforms perform diverse functions such as inducing growth

and differentiation of epithelial, glial, neuronal, and skeletal muscle cells;

inducing expression of acetylcholine receptor in synaptic vesicles during

the formation of the neuromuscular junction; stimulating lobuloalveolar

budding and milk production in the mammary gland and inducing

differentiation of mammary tumor cells; stimulating Schwann cell

proliferation; implication in the development of the myocardium such as

trabeculation of the developing heart. Isoform 10 may play a role in motor

and sensory neuron development.
NRG1 Sequence databases
EMBL DDBJ GenBank
NRG1 3D structure databases
ModBase
NRG1 Protein-protein interaction databases
STRING
NRG1 Proteomic databases
PRIDE
NRG1 Genome annotation databases
Ensembl GeneID KEGG UCSC
NRG1 Organism specific databases
CTD MGI
NRG1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
NRG1 Gene expression databases
Bgee ArrayExpress Genevestigator
NRG1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY