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Human B-cell linker protein (a.a.1–456)

BLNK Swiss Prot#

Q8WV28

BLNK Protein names

B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing

a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain

protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa)

(SLP-65)

BLNK Gene names

BLNK (BASH) (SLP65)

Organism

Human

BLNK Entry name

TNR1A_HUMAN

BLNK Codon optimized cDNA Clone

BLNK CDNA Cat#

RPE0735

cDNA Tag

cDNA BLNK Contains A 6x histidine tag

Condon optimized BLNK CDNA Formulation

Liquid

Condon optimized BLNK CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized BLNK cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant BLNK Protein

Recombinant BLNK Protein Cat#

PE0735

BLNK Protein Source

Recombinant protein.

Recombinant BLNK Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant BLNK Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant BLNK Protein Activity

N/A

Recombinant protein Tag

Recombinant BLNK contains A 6x histidine tag

Recombinant BLNK Protein Formulation

Liquid

Recombinant BLNK Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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BLNK Protein family

BLNK Subcellular locations

Cytoplasm. Cell membrane.

BLNK FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Functions as a central linker protein that bridges kinases

associated with the B-cell receptor (BCR) with a multitude of signaling

pathways, regulating biological outcomes of B-cell function and

development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38

and JNK. Modulates AP1 activation. Important for the activation of NF-

kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and

PLCG2 activation and Ca(2+) mobilization and is required for trafficking of

the BCR to late endosomes. However, does not seem to be required for pre-

BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3)

kinase signaling. May be required for the RAC1-JNK pathway. Plays a

critical role in orchestrating the pro-B cell to pre-B cell transition (By

similarity). Plays an important role in BCR-induced B-cell apoptosis.

BLNK Sequence databases

EMBL

DDBJ

GenBank

BLNK 3D structure databases

ModBase

BLNK Protein-protein interaction databases

STRING

BLNK Proteomic databases

PRIDE

BLNK Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

BLNK Organism specific databases

CTD

MGI

BLNK Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BLNK Gene expression databases

Bgee

ArrayExpress

Genevestigator

BLNK Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY