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Human Serine/threonine-protein kinase mTOR (a.a.2182–2516)

FRAP1 Swiss Prot#

P42345

FRAP1 Protein names

Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (Mammalian target of

rapamycin) (mTOR) (FKBP12-rapamycin complex-associated protein) (FK506-

binding protein 12-rapamycin complex-associated protein 1) (Rapamycin

target protein) (RAPT1)

FRAP1 Gene names

FRAP1 (FRAP) (FRAP2)

Organism

Human

FRAP1 Entry name

TNR6_HUMAN

FRAP1 Codon optimized cDNA Clone

FRAP1 CDNA Cat#

RPE0606

cDNA Tag

cDNA FRAP1 Contains A 6x histidine tag

Condon optimized FRAP1 CDNA Formulation

Liquid

Condon optimized FRAP1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized FRAP1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant FRAP1 Protein

Recombinant FRAP1 Protein Cat#

PE0606

FRAP1 Protein Source

Recombinant protein.

Recombinant FRAP1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant FRAP1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant FRAP1 Protein Activity

N/A

Recombinant protein Tag

Recombinant FRAP1 contains A 6x histidine tag

Recombinant FRAP1 Protein Formulation

Liquid

Recombinant FRAP1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Place Order for Recombinant FRAP1 Protein or cDNA

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FRAP1 Protein family

PI3/PI4-kinase family

FRAP1 Subcellular locations

Endoplasmic reticulum membrane; Peripheral membrane protein;

Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane

protein; Cytoplasmic side. Mitochondrion outer membrane; Peripheral

membrane protein; Cytoplasmic side. Lysosome. Cytoplasm. Nucle

FRAP1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Kinase subunit of both mTORC1 and mTORC2, which regulates

cell growth and survival in response to nutrient and hormonal signals.

mTORC1 is activated in response to growth factors or amino-acids. Growth

factor-stimulated mTORC1 activation involves AKT1-mediated

phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB

GTPase that potently activates the protein kinase activity of mTORC1.

Amino-acid-signaling to mTORC1 requires its relocalization to the

lysosomes mediated by the Ragulator complex and the Rag GTPases.

Activated mTORC1 up-regulates protein synthesis by phosphorylating key

regulators of mRNA translation and ribosome synthesis. mTORC1

phosphorylates EIF4EBP1 and releases it from inhibiting the elongation

initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at

'Thr-421', which then promotes protein synthesis by phosphorylating PDCD4

and targeting it for degradation. Phosphorylates MAF1 leading to attenuation

of its RNA polymerase III-repressive function. mTORC2 is also activated by

growth. factors, but seems to be nutrient-insensitive. mTORC2 seems to

function upstream of Rho GTPases to regulate the actin cytoskeleton,

probably by activating one or more Rho-type guanine nucleotide exchange

factors. mTORC2 promotes the serum-induced formation of stress-fibers or

F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation,

which may facilitate the phosphorylation of the activation loop of AKT1 on

'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2

regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates

the phosphorylation of PRKCA on 'Ser-657'.

FRAP1 Sequence databases

EMBL

DDBJ

GenBank

FRAP1 3D structure databases

ModBase

FRAP1 Protein-protein interaction databases

STRING

FRAP1 Proteomic databases

PRIDE

FRAP1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

FRAP1 Organism specific databases

CTD

MGI

FRAP1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN