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Human Cyclin-dependent kinase inhibitor 2A, isoform 4 (a.a.1–173)
CDKN2A Swiss Prot#
Q8N726
CDKN2A Protein names
Cyclin-dependent kinase inhibitor 2A, isoform 4 (p14ARF) (p19ARF)
CDKN2A Gene names
CDKN2A (CDKN2) (MLM)
Organism
Human
CDKN2A Entry name
CD2A2_HUMAN
CDKN2A Codon optimized cDNA Clone
CDKN2A CDNA Cat#
RPE0434
cDNA Tag
cDNA CDKN2A Contains A 6x histidine tag
Condon optimized CDKN2A CDNA Formulation
Liquid
Condon optimized CDKN2A CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized CDKN2A cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant CDKN2A Protein
Recombinant CDKN2A Protein Cat#
PE0434
CDKN2A Protein Source
Recombinant protein.
Recombinant CDKN2A Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant CDKN2A Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant CDKN2A Protein Activity
N/A
Recombinant protein Tag
Recombinant CDKN2A contains A 6x histidine tag
Recombinant CDKN2A Protein Formulation
Liquid
Recombinant CDKN2A Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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CDKN2A Protein family
-
CDKN2A Subcellular locations
Nucleus > nucleolus. Nucleus > nucleoplasm.
CDKN2A FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts

as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic

shuttling by sequestering it in the nucleolus. This inhibits the oncogenic

action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing

p53-dependent transactivation and apoptosis. Also induces G2 arrest and

apoptosis in a p53-independent manner by preventing the activation of

cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-

induced transcriptional repression. Binds to E2F1 and MYC and blocks their

transcriptional activator activity but has no effect on MYC transcriptional

repression. Binds to TOP1/TOPOI and stimulates its activity. This complex

binds to rRNA gene promoters and may play a role in rRNA transcription

and/or maturation. Interacts with NPM1/B23 and promotes its

polyubiquitination and degradation, thus inhibiting rRNA processing.

Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination.

Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its

binding partners including MDM2 and E2F1. Binds to HUWE1 and represses

its ubiquitin ligase activity. May play a role in controlling cell proliferation

and apoptosis during mammary gland development.
CDKN2A Sequence databases
EMBL DDBJ GenBank
CDKN2A 3D structure databases
ModBase
CDKN2A Protein-protein interaction databases
STRING
CDKN2A Proteomic databases
PRIDE
CDKN2A Genome annotation databases
Ensembl GeneID KEGG UCSC
CDKN2A Organism specific databases
CTD MGI
CDKN2A Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CDKN2A Gene expression databases
Bgee ArrayExpress Genevestigator
CDKN2A Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY