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Human Ras-related C3 botulinum toxin substrate 1 (a.a.1–189)

RAC1 Swiss Prot#

P63000

RAC1 Protein names

Ras-related C3 botulinum toxin substrate 1 (p21-Rac1) (Ras-like protein

TC25) (Cell migration-inducing gene 5 protein)

RAC1 Gene names

RAC1 (MIG5)

Organism

Human

RAC1 Entry name

RAC1_HUMAN

RAC1 Codon optimized cDNA Clone

RAC1 CDNA Cat#

RPE0452

cDNA Tag

cDNA RAC1 Contains A 6x histidine tag

Condon optimized RAC1 CDNA Formulation

Liquid

Condon optimized RAC1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized RAC1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RAC1 Protein

Recombinant RAC1 Protein Cat#

PE0452

RAC1 Protein Source

Recombinant protein.

Recombinant RAC1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant RAC1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant RAC1 Protein Activity

N/A

Recombinant protein Tag

Recombinant RAC1 contains A 6x histidine tag

Recombinant RAC1 Protein Formulation

Liquid

Recombinant RAC1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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RAC1 Protein family

Small GTPase superfamily, Rho family

RAC1 Subcellular locations

Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome.

RAC1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Plasma membrane-associated small GTPase which cycles

between active GTP-bound and inactive GDP-bound states. In its active

state, binds to a variety of effector proteins to regulate cellular responses

such as secretory processes, phagocytosis of apoptotic cells, epithelial cell

polarization and growth-factor induced formation of membrane ruffles. Rac1

p21/rho GDI heterodimer is the active component of the cytosolic factor

sigma 1, which is involved in stimulation of the NADPH oxidase activity in

macrophages (By similarity). Essential for the SPATA13-mediated regulation

of cell migration and adhesion assembly and disassembly.; FUNCTION:

Isoform B has an accelerated GEF-independent GDP/GTP exchange and an

impaired GTP hydrolysis, which is restored partially by GTPase-activating

proteins. It is able to bind to the GTPase-binding domain of PAK but not full-

length PAK in a GTP-dependent manner, suggesting that the insertion does

not completely abolish effector interaction.

RAC1 Sequence databases

EMBL

DDBJ

GenBank

RAC1 3D structure databases

ModBase

RAC1 Protein-protein interaction databases

STRING

RAC1 Proteomic databases

PRIDE

RAC1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

RAC1 Organism specific databases

CTD

MGI

RAC1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RAC1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

RAC1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY