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Human Proto-oncogene tyrosine-protein kinase LCK (a.a.245–498)

LCK Swiss Prot#

P06239

LCK Protein names

Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Lymphocyte cell-

specific protein-tyrosine kinase) (p56-LCK) (LSK) (T cell-specific protein-

tyrosine kinase)

LCK Gene names

LCK

Organism

Human

LCK Entry name

PDIA1_HUMAN

LCK Codon optimized cDNA Clone

LCK CDNA Cat#

RPE0796

cDNA Tag

cDNA LCK Contains A 6x histidine tag

Condon optimized LCK CDNA Formulation

Liquid

Condon optimized LCK CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized LCK cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant LCK Protein

Recombinant LCK Protein Cat#

PE0796

LCK Protein Source

Recombinant protein.

Recombinant LCK Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant LCK Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant LCK Protein Activity

N/A

Recombinant protein Tag

Recombinant LCK contains A 6x histidine tag

Recombinant LCK Protein Formulation

Liquid

Recombinant LCK Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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LCK Protein family

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily

LCK Subcellular locations

Cytoplasm. Cell membrane; Lipid-anchor; Cytoplasmic side.

LCK FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Tyrosine kinase that plays an essential role for the selection and

maturation of developing T-cell in the thymus and in mature T-cell function.

Is constitutively associated with the cytoplasmic portions of the CD4 and

CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-

linked signal transduction pathways. Association of the TCR with a peptide

antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with

MHC class II and class I molecules, respectively, and thereby recruits the

associated LCK to the vicinity of the TCR/CD3 complex. LCK then

phosphorylates tyrosines residues within the immunoreceptor tyrosines-

based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma

chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In

addition, contributes to signaling by other receptor molecules. Associates

directly with the cytoplasmic tail of CD2, and upon engagement of the CD2

molecule, LCK undergoes hyperphosphorylation and activation. Also plays a

role in the IL2 receptor-linked signaling pathway that controls T-cell

proliferative response. Binding of IL2 to its receptor results in increased

activity of LCK. Is expressed at all stages of thymocyte development and is

required for the regulation of maturation events that are governed by both

pre-TCR and mature alpha beta TCR. Phosphorylates RUNX3.

LCK Sequence databases

EMBL

DDBJ

GenBank

LCK 3D structure databases

ModBase

LCK Protein-protein interaction databases

STRING

LCK Proteomic databases

PRIDE

LCK Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

LCK Organism specific databases

CTD

MGI

LCK Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

LCK Gene expression databases

Bgee

ArrayExpress

Genevestigator

LCK Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY