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Human Retinoblastoma-associated protein (a.a.373–771)
RB1 Swiss Prot#
P06400
RB1 Protein names
Retinoblastoma-associated protein (pRb) (Rb) (pp110) (p105-Rb)
RB1 Gene names
RB1
Organism
Human
RB1 Entry name
NTRK2_HUMAN
RB1 Codon optimized cDNA Clone
RB1 CDNA Cat#
RPE0673
cDNA Tag
cDNA RB1 Contains A 6x histidine tag
Condon optimized RB1 CDNA Formulation
Liquid
Condon optimized RB1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized RB1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RB1 Protein
Recombinant RB1 Protein Cat#
PE0673
RB1 Protein Source
Recombinant protein.
Recombinant RB1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RB1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RB1 Protein Activity
N/A
Recombinant protein Tag
Recombinant RB1 contains A 6x histidine tag
Recombinant RB1 Protein Formulation
Liquid
Recombinant RB1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Place Order for Recombinant RB1 Protein or cDNA
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RB1 Protein family
Retinoblastoma protein (RB) family
RB1 Subcellular locations
Nucleus.
RB1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Key regulator of entry into cell division that acts as a tumor

suppressor. Acts as a transcription repressor of E2F1 target genes. The

underphosphorylated, active form of RB1 interacts with E2F1 and represses

its transcription activity, leading to cell cycle arrest. Directly involved in

heterochromatin formation by maintaining overall chromatin structure and,

in particular, that of constitutive heterochromatin by stabilizing histone

methylation. Recruits and targets histone methyltransferases SUV39H1,

SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression.

Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase

activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by

recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In

resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-

dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon

calcium influx, RB1 is dephosphorylated by calcineurin, which leads to

release of the repressor complex (By similarity). In case of viral infections,

interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A

protein induce the disassembly of RB1-E2F1 complex thereby disrupting

RB1's activity.
RB1 Sequence databases
EMBL DDBJ GenBank
RB1 3D structure databases
ModBase
RB1 Protein-protein interaction databases
STRING
RB1 Proteomic databases
PRIDE
RB1 Genome annotation databases
Ensembl GeneID KEGG UCSC
RB1 Organism specific databases
CTD MGI
RB1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
RB1 Gene expression databases
Bgee ArrayExpress Genevestigator
RB1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY