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Human Von Hippel-Lindau disease tumor suppressor (a.a.1–213)
VHL Swiss Prot#
P40337
VHL Protein names
Von Hippel-Lindau disease tumor suppressor (pVHL) (Protein G7)
VHL Gene names
VHL
Organism
Human
VHL Entry name
VHL_HUMAN
VHL Codon optimized cDNA Clone
VHL CDNA Cat#
RPE0471
cDNA Tag
cDNA VHL Contains A 6x histidine tag
Condon optimized VHL CDNA Formulation
Liquid
Condon optimized VHL CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized VHL cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant VHL Protein
Recombinant VHL Protein Cat#
PE0471
VHL Protein Source
Recombinant protein.
Recombinant VHL Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant VHL Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant VHL Protein Activity
N/A
Recombinant protein Tag
Recombinant VHL contains A 6x histidine tag
Recombinant VHL Protein Formulation
Liquid
Recombinant VHL Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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VHL Protein family
-
VHL Subcellular locations
Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Cytoplasm.

Nucleus.
VHL FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Involved in the ubiquitination and subsequent proteasomal

degradation via the von Hippel-Lindau ubiquitination complex. Seems to act

as target recruitment subunit in the E3 ubiquitin ligase complex and

recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic

conditions. Involved in transcriptional repression through interaction with

HIF1A, HIF1AN and histone deacetylases.
VHL Sequence databases
EMBL DDBJ GenBank
VHL 3D structure databases
ModBase
VHL Protein-protein interaction databases
STRING
VHL Proteomic databases
PRIDE
VHL Genome annotation databases
Ensembl GeneID KEGG UCSC
VHL Organism specific databases
CTD MGI
VHL Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
VHL Gene expression databases
Bgee ArrayExpress Genevestigator
VHL Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY