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Human Insulin receptor (a.a.763–956)

INSR Swiss Prot#

P06213

INSR Protein names

Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin

receptor subunit alpha; Insulin receptor subunit beta]

INSR Gene names

INSR

Organism

Human

INSR Entry name

INSR_HUMAN

INSR Codon optimized cDNA Clone

INSR CDNA Cat#

RPE0455

cDNA Tag

cDNA INSR Contains A 6x histidine tag

Condon optimized INSR CDNA Formulation

Liquid

Condon optimized INSR CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized INSR cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant INSR Protein

Recombinant INSR Protein Cat#

PE0455

INSR Protein Source

Recombinant protein.

Recombinant INSR Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant INSR Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant INSR Protein Activity

N/A

Recombinant protein Tag

Recombinant INSR contains A 6x histidine tag

Recombinant INSR Protein Formulation

Liquid

Recombinant INSR Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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INSR Protein family

Protein kinase superfamily, Tyr protein kinase family, Insulin receptor

subfamily

INSR Subcellular locations

Membrane; Single-pass type I membrane protein.

INSR FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: This receptor binds insulin and has a tyrosine-protein kinase

activity. Isoform Short has a higher affinity for insulin. Mediates the

metabolic functions of insulin. Binding to insulin stimulates association of

the receptor with downstream mediators including IRS1 and

phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by

binding to the p85 regulatory subunit, or indirectly via IRS1. When present

in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that

hybrid receptors composed of IGF1R and INSR isoform Long are activated

with a high affinity by IGF1, with low affinity by IGF2 and not significantly

activated by insulin, and that hybrid receptors composed of IGF1R and INSR

isoform Short are activated by IGF1, IGF2 and insulin. In contrast,

PubMed:16831875 shows that hybrid receptors composed of IGF1R and

INSR isoform Long and hybrid receptors composed of IGF1R and INSR

isoform Short have similar binding characteristics, both bind IGF1 and

have a low affinity for insulin.

INSR Sequence databases

EMBL

DDBJ

GenBank

INSR 3D structure databases

ModBase

INSR Protein-protein interaction databases

STRING

INSR Proteomic databases

PRIDE

INSR Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

INSR Organism specific databases

CTD

MGI

INSR Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

INSR Gene expression databases

Bgee

ArrayExpress

Genevestigator

INSR Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY