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Human E3 ubiquitin-protein ligase parkin (a.a.1–465)
PARK2 Swiss Prot#
O60260
PARK2 Protein names
E3 ubiquitin-protein ligase parkin (EC 6.3.2.-) (Parkinson juvenile disease

protein 2) (Parkinson disease protein 2)
PARK2 Gene names
PARK2 (PRKN)
Organism
Human
PARK2 Entry name
HXK4_HUMAN
PARK2 Codon optimized cDNA Clone
PARK2 CDNA Cat#
RPE0745
cDNA Tag
cDNA PARK2 Contains A 6x histidine tag
Condon optimized PARK2 CDNA Formulation
Liquid
Condon optimized PARK2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PARK2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PARK2 Protein
Recombinant PARK2 Protein Cat#
PE0745
PARK2 Protein Source
Recombinant protein.
Recombinant PARK2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PARK2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PARK2 Protein Activity
N/A
Recombinant protein Tag
Recombinant PARK2 contains A 6x histidine tag
Recombinant PARK2 Protein Formulation
Liquid
Recombinant PARK2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PARK2 Protein family
RBR family, Parkin subfamily
PARK2 Subcellular locations
Cytoplasm. Nucleus. Endoplasmic reticulum. Cytoplasm > cytosol.
PARK2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Functions within a multiprotein E3 ubiquitin ligase complex,

catalyzing the covalent attachment of ubiquitin moieties onto substrate

proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa

O-linked glycosylated isoform of SNCAIP, SEPT5, ZNF746 and AIMP2. May

play a more general role in the ubiquitin proteasomal pathway by

participating in the removal and/or detoxification of abnormally folded or

damaged protein. Limits the production of reactive oxygen species (ROS).

Loss of this ubiquitin ligase activity appears to be the mechanism

underlying pathogenesis of PARK2. Promotes the autophagic degradation of

dysfunctional depolarized mitochondria. Mediates 'Lys-48'-linked

polyubiquitination of ZNF746, followed by degradation of ZNF746 by the

proteasome; possibly playing a role in role in regulation of neuron death.

May protect neurons against alpha synuclein toxicity, proteasomal

dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May

play a role in controlling neurotransmitter trafficking at the presynaptic

terminal and in calcium-dependent exocytosis. Regulates cyclin E during

neuronal apoptosis. May represent a tumor suppressor gene.
PARK2 Sequence databases
EMBL DDBJ GenBank
PARK2 3D structure databases
ModBase
PARK2 Protein-protein interaction databases
STRING
PARK2 Proteomic databases
PRIDE
PARK2 Genome annotation databases
Ensembl GeneID KEGG UCSC
PARK2 Organism specific databases
CTD MGI
PARK2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PARK2 Gene expression databases
Bgee ArrayExpress Genevestigator
PARK2 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY