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Human PTHLH (PTHRP) (a.a. 37-177)
PTHLH Swiss Prot#
P12272
PTHLH Protein names
Parathyroid hormone-related protein (PTH-rP) (PTHrP) [Cleaved into:

PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]
PTHLH Gene names
PTHLH (PTHRP)
Organism
Human
PTHLH Entry name
PTHR_HUMAN
PTHLH Codon optimized cDNA Clone
PTHLH CDNA Cat#
RPE0036
cDNA Tag
cDNA PTHLH Contains A 6x histidine tag
Condon optimized PTHLH CDNA Formulation
Liquid
Condon optimized PTHLH CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PTHLH cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PTHLH Protein
Recombinant PTHLH Protein Cat#
PE0036
PTHLH Protein Source
Recombinant protein.
Recombinant PTHLH Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PTHLH Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PTHLH Protein Activity
N/A
Recombinant protein Tag
Recombinant PTHLH contains A 6x histidine tag
Recombinant PTHLH Protein Formulation
Liquid
Recombinant PTHLH Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PTHLH Protein family
Parathyroid hormone family
PTHLH Subcellular locations
Cytoplasm. Nucleus. Secreted.
PTHLH FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular

and organ growth, development, migration, differentiation and survival and

of epithelial calcium ion transport. Regulates endochondral bone

development and epithelial-mesenchymal interactions during the formation

of the mammary glands and teeth. Required for skeletal homeostasis.

Promotes mammary mesenchyme differentiation and bud outgrowth by

modulating mesenchymal cell responsiveness to BMPs. Upregulates

BMPR1A expression in the mammary mesenchyme and this increases the

sensitivity of these cells to BMPs and allows them to respond to BMP4 in a

paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in

turn, triggers epithelial outgrowth and augments MSX2 expression, which

causes the mammary mesenchyme to inhibit hair follicle formation within the

nipple sheath (By similarity). Promotes colon cancer cell migration and

invasion in an integrin alpha-6/beta-1-dependent manner through activation

of Rac1.; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone

resorption.
PTHLH Sequence databases
EMBL DDBJ GenBank
PTHLH 3D structure databases
ModBase
PTHLH Protein-protein interaction databases
STRING
PTHLH Proteomic databases
PRIDE
PTHLH Genome annotation databases
Ensembl GeneID KEGG UCSC
PTHLH Organism specific databases
CTD MGI
PTHLH Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PTHLH Gene expression databases
Bgee ArrayExpress Genevestigator
PTHLH Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY