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Human SHC-transforming protein 1 (a.a.1–583)

SHC1 Swiss Prot#

P29353

SHC1 Protein names

SHC-transforming protein 1 (Src homology 2 domain-containing-

transforming protein C1) (SH2 domain protein C1)

SHC1 Gene names

SHC1 (SHC) (SHCA)

Organism

Human

SHC1 Entry name

DOPO_HUMAN

SHC1 Codon optimized cDNA Clone

SHC1 CDNA Cat#

RPE0854

cDNA Tag

cDNA SHC1 Contains A 6x histidine tag

Condon optimized SHC1 CDNA Formulation

Liquid

Condon optimized SHC1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized SHC1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SHC1 Protein

Recombinant SHC1 Protein Cat#

PE0854

SHC1 Protein Source

Recombinant protein.

Recombinant SHC1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant SHC1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant SHC1 Protein Activity

N/A

Recombinant protein Tag

Recombinant SHC1 contains A 6x histidine tag

Recombinant SHC1 Protein Formulation

Liquid

Recombinant SHC1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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SHC1 Protein family

SHC1 Subcellular locations

Cytoplasm. Mitochondrion matrix. Mitochondrion.

SHC1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Signaling adapter that couples activated growth factor

receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once

phosphorylated, couple activated receptor tyrosine kinases to Ras via the

recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic

propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may

thus function as initiators of the Ras signaling cascade in various non-

neuronal systems. Isoform p66Shc does not mediate Ras activation, but is

involved in signal transduction pathways that regulate the cellular response

to oxidative stress and life span. Isoform p66Shc acts as a downstream

target of the tumor suppressor p53 and is indispensable for the ability of

stress p53 to induce elevation of intracellular oxidants,

cytochrome c release and apoptosis. The expression of isoform p66Shc has

been correlated with life span (By similarity).

SHC1 Sequence databases

EMBL

DDBJ

GenBank

SHC1 3D structure databases

ModBase

SHC1 Protein-protein interaction databases

STRING

SHC1 Proteomic databases

PRIDE

SHC1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

SHC1 Organism specific databases

CTD

MGI

SHC1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SHC1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

SHC1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY