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Human Sonic hedgehog protein (a.a.24–197)

SHH Swiss Prot#

Q15465

SHH Protein names

Sonic hedgehog protein (SHH) (HHG-1) [Cleaved into: Sonic hedgehog

protein N-product; Sonic hedgehog protein C-product]

SHH Gene names

SHH

Organism

Human

SHH Entry name

RXRA_HUMAN

SHH Codon optimized cDNA Clone

SHH CDNA Cat#

RPE0742

cDNA Tag

cDNA SHH Contains A 6x histidine tag

Condon optimized SHH CDNA Formulation

Liquid

Condon optimized SHH CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized SHH cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SHH Protein

Recombinant SHH Protein Cat#

PE0742

SHH Protein Source

Recombinant protein.

Recombinant SHH Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant SHH Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant SHH Protein Activity

N/A

Recombinant protein Tag

Recombinant SHH contains A 6x histidine tag

Recombinant SHH Protein Formulation

Liquid

Recombinant SHH Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Place Order for Recombinant SHH Protein or cDNA

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SHH Protein family

Hedgehog family

SHH Subcellular locations

Secreted > extracellular space. Cell membrane; Lipid-anchor.

SHH FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Binds to the patched (PTC) receptor, which functions in

association with smoothened (SMO), to activate the transcription of target

genes. In the absence of SHH, PTC represses the constitutive signaling

activity of SMO. Also regulates another target, the gli oncogene.

Intercellular signal essential for a variety of patterning events during

development: signal produced by the notochord that induces ventral cell

fate in the neural tube and somites, and the polarizing signal for patterning

of the anterior-posterior axis of the developing limb bud. Displays both floor

plate- and motor neuron-inducing activity. The threshold concentration of N-

product required for motor neuron induction is 5-fold lower than that

required for floor plate induction (By similarity).

SHH Sequence databases

EMBL

DDBJ

GenBank

SHH 3D structure databases

ModBase

SHH Protein-protein interaction databases

STRING

SHH Proteomic databases

PRIDE

SHH Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

SHH Organism specific databases

CTD

MGI

SHH Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SHH Gene expression databases

Bgee

ArrayExpress

Genevestigator

SHH Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY