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Human Sterol regulatory element-binding protein 1 (a.a.1–490)

SREBF1 Swiss Prot#

P36956

SREBF1 Protein names

Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory

element-binding transcription factor 1) [Cleaved into: Processed sterol

regulatory element-binding protein 1]

SREBF1 Gene names

SREBF1 (SREBP1)

Organism

Human

SREBF1 Entry name

THA_HUMAN

SREBF1 Codon optimized cDNA Clone

SREBF1 CDNA Cat#

RPE0772

cDNA Tag

cDNA SREBF1 Contains A 6x histidine tag

Condon optimized SREBF1 CDNA Formulation

Liquid

Condon optimized SREBF1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized SREBF1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SREBF1 Protein

Recombinant SREBF1 Protein Cat#

PE0772

SREBF1 Protein Source

Recombinant protein.

Recombinant SREBF1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant SREBF1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant SREBF1 Protein Activity

N/A

Recombinant protein Tag

Recombinant SREBF1 contains A 6x histidine tag

Recombinant SREBF1 Protein Formulation

Liquid

Recombinant SREBF1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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SREBF1 Protein family

SREBP family

SREBF1 Subcellular locations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi

apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle >

COPII-coated vesicle membrane; Multi-pass membrane protein. Nucleus.

SREBF1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Transcriptional activator required for lipid homeostasis.

Regulates transcription of the LDL receptor gene as well as the fatty acid

and to a lesser degree the cholesterol synthesis pathway (By similarity).

Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has

dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3')

and to SRE-1 (5'-ATCACCCCAC-3').

SREBF1 Sequence databases

EMBL

DDBJ

GenBank

SREBF1 3D structure databases

ModBase

SREBF1 Protein-protein interaction databases

STRING

SREBF1 Proteomic databases

PRIDE

SREBF1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

SREBF1 Organism specific databases

CTD

MGI

SREBF1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SREBF1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

SREBF1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY