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Human Protein Wnt-5a (a.a.62–380)

WNT5A Swiss Prot#

P41221

WNT5A Protein names

Protein Wnt-5a

WNT5A Gene names

WNT5A

Organism

Human

WNT5A Entry name

FOS_HUMAN

WNT5A Codon optimized cDNA Clone

WNT5A CDNA Cat#

RPE0655

cDNA Tag

cDNA WNT5A Contains A 6x histidine tag

Condon optimized WNT5A CDNA Formulation

Liquid

Condon optimized WNT5A CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized WNT5A cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant WNT5A Protein

Recombinant WNT5A Protein Cat#

PE0655

WNT5A Protein Source

Recombinant protein.

Recombinant WNT5A Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant WNT5A Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant WNT5A Protein Activity

N/A

Recombinant protein Tag

Recombinant WNT5A contains A 6x histidine tag

Recombinant WNT5A Protein Formulation

Liquid

Recombinant WNT5A Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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WNT5A Protein family

Wnt family

WNT5A Subcellular locations

Secreted > extracellular space > extracellular matrix.

WNT5A FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Ligand for members of the frizzled family of seven

transmembrane receptors. Can activate or inhibit canonical Wnt signaling,

depending on receptor context. In the presence of FZD4, activates beta-

catenin signaling. In the presence of ROR2, inhibits the canonical Wnt

pathway by promoting beta-catenin degradation through a GSK3-independent

pathway which involves down-regulation of beta-catenin-induced reporter

gene expression. Suppression of the canonical pathway allows

chondrogenesis to occur and inhibits tumor formation. Stimulates cell

migration. Decreases proliferation, migration, invasiveness and

clonogenicity of carcinoma cells and may act as a tumor suppressor.

Mediates motility of melanoma cells. Required during embryogenesis for

extension of the primary anterior-posterior axis and for outgrowth of limbs

and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

WNT5A Sequence databases

EMBL

DDBJ

GenBank

WNT5A 3D structure databases

ModBase

WNT5A Protein-protein interaction databases

STRING

WNT5A Proteomic databases

PRIDE

WNT5A Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

WNT5A Organism specific databases

CTD

MGI

WNT5A Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

WNT5A Gene expression databases

Bgee

ArrayExpress

Genevestigator

WNT5A Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY