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Human AP2M1 (CLAPM1) (KIAA0109) (a.a.1-435)
AP2M1 Swiss Prot#
Q96CW1
AP2M1 Protein names
AP-2 complex subunit mu-1 (Adaptin-mu2) (AP-2 mu-2 chain) (Plasma

membrane adaptor AP-2 50 kDa protein) (HA2 50 kDa subunit) (Clathrin

assembly protein complex 2 medium chain) (Clathrin coat assembly protein

AP50) (Clathrin coat-associated protein AP50)
AP2M1 Gene names
AP2M1 (CLAPM1) (KIAA0109)
Organism
Human
AP2M1 Entry name
AP2M1_HUMAN
AP2M1 Codon optimized cDNA Clone
AP2M1 CDNA Cat#
RPE0196
cDNA Tag
cDNA AP2M1 Contains A 6x histidine tag
Condon optimized AP2M1 CDNA Formulation
Liquid
Condon optimized AP2M1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized AP2M1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant AP2M1 Protein
Recombinant AP2M1 Protein Cat#
PE0196
AP2M1 Protein Source
Recombinant protein.
Recombinant AP2M1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant AP2M1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant AP2M1 Protein Activity
N/A
Recombinant protein Tag
Recombinant AP2M1 contains A 6x histidine tag
Recombinant AP2M1 Protein Formulation
Liquid
Recombinant AP2M1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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AP2M1 Protein family
Adaptor complexes medium subunit family
AP2M1 Subcellular locations
Cell membrane. Membrane > coated pit; Peripheral membrane protein;

Cytoplasmic side.
AP2M1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor

protein complexes function in protein transport via transport vesicles in

different membrane traffic pathways. Adaptor protein complexes are vesicle

coat components and appear to be involved in cargo selection and vesicle

formation. AP-2 is involved in clathrin-dependent endocytosis in which

cargo proteins are incorporated into vesicles surrrounded by clathrin

(clathrin-coated vesicles, CCVs) which are destined for fusion with the early

endosome. The clathrin lattice serves as a mechanical scaffold but is itself

unable to bind directly to membrane components. Clathrin-associated

adaptor protein (AP) complexes which can bind directly to both the clathrin

lattice and to the lipid and protein components of membranes are

considered to be the major clathrin adaptors contributing the CCV

formation. AP-2 also serves as a cargo receptor to selectively sort the

membrane proteins involved in receptor-mediated endocytosis. AP-2

seems to play a role in the recycling of synaptic vesicle membranes from

the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and

[ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of

transmembrane cargo molecules. AP-2 may also play a role in maintaining

normal post-endocytic trafficking through the ARF6-regulated, non-clathrin

pathway. The AP-2 mu subunit binds to transmembrane cargo proteins; it

recognizes the Y-X-X-Phi motifs. The surface region interacting with to the

Y-X-X-Phi motif is inaccessible in cytosolic AP-2, but becomes accessible

through a conformational change following phosphorylation of AP-2 mu

subunit at 'Tyr-156' in membrane-associated AP-2. The membrane-specific

phosphorylation event appears to involve assembled clathrin which

activates the AP-2 mu kinase AAK1 (By similarity).
AP2M1 Sequence databases
EMBL DDBJ GenBank
AP2M1 3D structure databases
ModBase
AP2M1 Protein-protein interaction databases
STRING
AP2M1 Proteomic databases
PRIDE
AP2M1 Genome annotation databases
Ensembl GeneID KEGG UCSC
AP2M1 Organism specific databases
CTD MGI
AP2M1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN