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Human KCNMB1 (a.a. 40-157)

KCNMB1 Swiss Prot#

Q16558

KCNMB1 Protein names

Calcium potassium channel subunit beta-1 (Calcium

potassium channel, subfamily M subunit beta-1) (Calcium

potassium channel subunit beta) (Maxi K channel subunit beta-1) (BK

channel subunit beta-1) (BKbeta1) (BKbeta) (Hbeta1)

KCNMB1 Gene names

KCNMB1

Organism

Human

KCNMB1 Entry name

KCMB1_HUMAN

KCNMB1 Codon optimized cDNA Clone

KCNMB1 CDNA Cat#

RPE0038

cDNA Tag

cDNA KCNMB1 Contains A 6x histidine tag

Condon optimized KCNMB1 CDNA Formulation

Liquid

Condon optimized KCNMB1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized KCNMB1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant KCNMB1 Protein

Recombinant KCNMB1 Protein Cat#

PE0038

KCNMB1 Protein Source

Recombinant protein.

Recombinant KCNMB1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant KCNMB1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant KCNMB1 Protein Activity

N/A

Recombinant protein Tag

Recombinant KCNMB1 contains A 6x histidine tag

Recombinant KCNMB1 Protein Formulation

Liquid

Recombinant KCNMB1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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KCNMB1 Protein family

KCNMB (TC 8.A.14.1) family, KCNMB1 subfamily

KCNMB1 Subcellular locations

Membrane; Multi-pass membrane protein.

KCNMB1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1

(maxiK) channel. Modulates the calcium sensitivity and gating kinetics of

KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the

apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies

KCNMA1 channel kinetics and alters its pharmacological properties. It

slows down the activation and the deactivation kinetics of the channel. Acts

as a negative regulator of smooth muscle contraction by enhancing the

calcium sensitivity to KCNMA1. Its presence is also a requirement for

internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-

1) triterpene glycoside and for external binding of the agonist hormone 17-

beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX)

toxin to KCNMA1 peptide blocker by increasing the CTX association rate and

decreasing the dissociation rate.

KCNMB1 Sequence databases

EMBL

DDBJ

GenBank

KCNMB1 3D structure databases

ModBase

KCNMB1 Protein-protein interaction databases

STRING

KCNMB1 Proteomic databases

PRIDE

KCNMB1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

KCNMB1 Organism specific databases

CTD

MGI

KCNMB1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

KCNMB1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

KCNMB1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY