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Human RAD51C (RAD51L2) (a.a.1-376)

RAD51C Swiss Prot#

O43502

RAD51C Protein names

DNA repair protein RAD51 homolog 3 (R51H3) (RAD51-like protein 2)

RAD51C Gene names

RAD51C (RAD51L2)

Organism

Human

RAD51C Entry name

RA51C_HUMAN

RAD51C Codon optimized cDNA Clone

RAD51C CDNA Cat#

RPE0153

cDNA Tag

cDNA RAD51C Contains A 6x histidine tag

Condon optimized RAD51C CDNA Formulation

Liquid

Condon optimized RAD51C CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized RAD51C cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RAD51C Protein

Recombinant RAD51C Protein Cat#

PE0153

RAD51C Protein Source

Recombinant protein.

Recombinant RAD51C Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant RAD51C Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant RAD51C Protein Activity

N/A

Recombinant protein Tag

Recombinant RAD51C contains A 6x histidine tag

Recombinant RAD51C Protein Formulation

Liquid

Recombinant RAD51C Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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RAD51C Protein family

RecA family, RAD51 subfamily

RAD51C Subcellular locations

Nucleus. Cytoplasm. Cytoplasm > perinuclear region. Mitochondrion.

RAD51C FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Essential for the homologous recombination (HR) pathway of

DNA repair. Involved in the homologous recombination repair (HRR)

pathway of double-stranded DNA breaks arising during DNA replication or

induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits

single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds

single-stranded DNA, single-stranded gaps in duplex DNA and specifically

to nicks in duplex DNA. Participates in branch migration and Holliday

junction resolution and thus is important for processing HR intermediates

late in the DNA repair process. Also has an early function in DNA repair in

facilitating phosphorylation of the checkpoint kinase CHK2 and thereby

transduction of the damage signal, leading to cell cycle arrest and HR

activation. Protects RAD51 from ubiquitin-mediated degradation that is

enhanced following DNA damage. Plays a role in regulating mitochondrial

DNA copy number under conditions of oxidative stress in the presence of

RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister

chromatid cohesion and genomic stability. Involved in maintaining

centrosome number in mitosis.

RAD51C Sequence databases

EMBL

DDBJ

GenBank

RAD51C 3D structure databases

ModBase

RAD51C Protein-protein interaction databases

STRING

RAD51C Proteomic databases

PRIDE

RAD51C Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

RAD51C Organism specific databases

CTD

MGI

RAD51C Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RAD51C Gene expression databases

Bgee

ArrayExpress

Genevestigator

RAD51C Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY