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Human TERF2 (TRBF2) (TRF2) (a.a.1-500)

TERF2 Swiss Prot#

Q15554

TERF2 Protein names

Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2)

(Telomeric DNA-binding protein)

TERF2 Gene names

TERF2 (TRBF2) (TRF2)

Organism

Human

TERF2 Entry name

TERF2_HUMAN

TERF2 Codon optimized cDNA Clone

TERF2 CDNA Cat#

RPE0242

cDNA Tag

cDNA TERF2 Contains A 6x histidine tag

Condon optimized TERF2 CDNA Formulation

Liquid

Condon optimized TERF2 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized TERF2 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant TERF2 Protein

Recombinant TERF2 Protein Cat#

PE0242

TERF2 Protein Source

Recombinant protein.

Recombinant TERF2 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant TERF2 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant TERF2 Protein Activity

N/A

Recombinant protein Tag

Recombinant TERF2 contains A 6x histidine tag

Recombinant TERF2 Protein Formulation

Liquid

Recombinant TERF2 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Place Order for Recombinant TERF2 Protein or cDNA

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TERF2 Protein family

TERF2 Subcellular locations

Nucleus. Chromosome > telomere.

TERF2 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and

plays a central role in telomere maintenance and protection against end-to-

end fusion of chromosomes. In addition to its telomeric DNA-binding role,

required to recruit a number of factors and enzymes required for telomere

protection, including the shelterin complex, TERF2IP/RAP1 and

DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is

involved in the regulation of telomere length and protection. Shelterin

associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by

telomerase and protects chromosome ends; without its protective activity,

telomeres are no longer hidden from the DNA damage surveillance and

chromosome ends are inappropriately processed by DNA repair pathways.

Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop)

formation by generating 3' single-stranded overhang at the leading end

telomeres: T loops have been proposed to protect chromosome ends from

degradation and repair. Required both to recruit DCLRE1B/Apollo to

telomeres and activate the exonuclease activity of DCLRE1B/Apollo.

Preferentially binds to positive supercoiled DNA. Together with

DCLRE1B/Apollo, required to control the amount of DNA topoisomerase

(TOP1, TOP2A and TOP2B) needed for telomere replication during fork

passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1

to telomeres, thereby participating in to repressing homology-directed repair

(HDR), which can affect telomere length.

TERF2 Sequence databases

EMBL

DDBJ

GenBank

TERF2 3D structure databases

ModBase

TERF2 Protein-protein interaction databases

STRING

TERF2 Proteomic databases

PRIDE

TERF2 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

TERF2 Organism specific databases

CTD

MGI

TERF2 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

TERF2 Gene expression databases

Bgee

ArrayExpress

Genevestigator

TERF2 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY