| Lcn2 Protein names |
| Neutrophil gelatinase-associated lipocalin (NGAL) (p25) (SV-40-induced |
| 24P3 protein) (Lipocalin-2) |
| Lcn2 Entry name |
| NGAL_MOUSE |
| Lcn2 Codon optimized cDNA Clone |
| cDNA Tag |
| cDNA Lcn2 Contains A 6x histidine tag |
| Condon optimized Lcn2 CDNA Formulation |
| Liquid |
| Condon optimized Lcn2 CDNA Storage |
| Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw |
| Condon optimized Lcn2 cDNA Applications |
| Applications: 1. Codon-optimized cDNA sequence designed for recombinant |
| protein production in both E.coli and Mammalian cell. The cDNA has been |
| cloned into E.coli expression vector with 6x Histidine tag.2. May be used as |
| RNAi assistance to restore the loss-of-function. |
| Recombinant Lcn2 Protein Cat# |
| PE0290 |
| Lcn2 Protein Source |
| Recombinant protein. |
| Recombinant Lcn2 Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Lcn2 Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Lcn2 Protein Activity |
| N/A |
| Recombinant protein Tag |
| Recombinant Lcn2 contains A 6x histidine tag |
| Recombinant Lcn2 Protein Formulation |
| Liquid |
| Recombinant Lcn2 Protein Storage |
| Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw |
| Lcn2 Protein family |
| Calycin superfamily, Lipocalin family |
| Lcn2 Subcellular locations |
| Secreted. |
| Lcn2 FUNCTION (According to UniProtKB/Swiss Prot) |
| FUNCTION: Iron-trafficking protein involved in multiple processes such as |
| apoptosis, innate immunity and renal development. Binds iron through |
| association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that |
| shares structural similarities with bacterial enterobactin, and delivers or |
| removes iron from the cell, depending on the context. Iron-bound form (holo- |
| 24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, |
| leading to release of iron and subsequent increase of intracellular iron |
| concentration. In contrast, association of the iron-free form (apo-24p3) with |
| the SLC22A17 (24p3R) receptor is followed by association with an |
| intracellular siderophore, iron chelation and iron transfer to the |
| extracellular medium, thereby reducing intracellular iron concentration. |
| Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded |
| form increases intracellular iron concentration without promoting apoptosis, |
| while iron-free form decreases intracellular iron levels, inducing |
| expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. |
| Involved in innate immunity, possibly by sequestrating iron, leading to limit |
| Lcn2 3D structure databases |
| ModBase |
| Lcn2 Protein-protein interaction databases |
| STRING |
| Lcn2 Proteomic databases |
| PRIDE |
| Lcn2 Organism specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY |
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